Biomaterial Database

High-performance liquid chromatographic determination of ketoprofen in blood and urine. 1979

R Farinotti, and G Mahuzier

A rapid, simple determination was developed for ketoprofen in biological fluids using high-performance liquid chromatography. The method requires selective extraction of this antirheumatic medicament and an internal standard with ether from the previously acidified plasma and urine. After evaporation of the ether, the residue is taken up by methanol and analyzed by reversed-phase liquid chromatography with detection at 254 nm. A concentration as low as 0.1 microgram/ml can be determined with a 0.5-ml sample.

UI	MeSH Term	Description	Entries
D007660	Ketoprofen	An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It is used in the treatment of rheumatoid arthritis and osteoarthritis.	Benzoylhydratropic Acid,19,583 RP,2-(3-Benzoylphenyl)propionic Acid,Alrheumat,Alrheumum,Orudis,Profenid,RP-19583,RP 19583,RP, 19,583,RP19583
D008722	Methods	A series of steps taken in order to conduct research.	Techniques,Methodological Studies,Methodological Study,Procedures,Studies, Methodological,Study, Methodological,Method,Procedure,Technique
D010666	Phenylpropionates	Derivatives of 3-phenylpropionic acid, including its salts and esters.
D002851	Chromatography, High Pressure Liquid	Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.	Chromatography, High Performance Liquid,Chromatography, High Speed Liquid,Chromatography, Liquid, High Pressure,HPLC,High Performance Liquid Chromatography,High-Performance Liquid Chromatography,UPLC,Ultra Performance Liquid Chromatography,Chromatography, High-Performance Liquid,High-Performance Liquid Chromatographies,Liquid Chromatography, High-Performance
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man