Biomaterial Database

Systemic administration of prostaglandin E1 produces hypothermic effects in unanesthetized rats. 1979

M T Lin

The effects of intraperitoneal administration of prostaglandin E1 (PGE1) on thermoregulatory responses were assessed in unanesthetized rats at ambient temperatures (Ta) of 8, 22 and 29 degrees C. The body temperatures, metabolic rate, respiratory evaporative heat loss and vasomotor activity in response to PGE1 were observed. Intraperitoneal administration of PGE1 produced dose-dependent hypothermia at Ta's of both 8 and 22 degrees C. The PGE1 hypothermia was due to both the decreased metabolic rate and the cutaneous vasodilation. However, at a Ta of 29 degrees C, intraperitoneal administration of PGE1 produced no changes in rectal temperature, since the thermoregulatory responses were not affected by PGE1 application at this Ta. The data indicate that peripheral administration of PGE1 decreases metabolic heat production and increases heat loss, which leads to hypothermia in rats, in contrast to hyperthermia seen after central administration.

UI	MeSH Term	Description	Entries
D007274	Injections, Intraperitoneal	Forceful administration into the peritoneal cavity of liquid medication, nutrient, or other fluid through a hollow needle piercing the abdominal wall.	Intraperitoneal Injections,Injection, Intraperitoneal,Intraperitoneal Injection
D008297	Male		Males
D011458	Prostaglandins E	(11 alpha,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid (PGE(1)); (5Z,11 alpha,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid (PGE(2)); and (5Z,11 alpha,13E,15S,17Z)-11,15-dihydroxy-9-oxoprosta-5,13,17-trien-1-oic acid (PGE(3)). Three of the six naturally occurring prostaglandins. They are considered primary in that no one is derived from another in living organisms. Originally isolated from sheep seminal fluid and vesicles, they are found in many organs and tissues and play a major role in mediating various physiological activities.	PGE
D012007	Rectum	The distal segment of the LARGE INTESTINE, between the SIGMOID COLON and the ANAL CANAL.	Rectums
D001831	Body Temperature	The measure of the level of heat of a human or animal.	Organ Temperature,Body Temperatures,Organ Temperatures,Temperature, Body,Temperature, Organ,Temperatures, Body,Temperatures, Organ
D001833	Body Temperature Regulation	The processes of heating and cooling that an organism uses to control its temperature.	Heat Loss,Thermoregulation,Regulation, Body Temperature,Temperature Regulation, Body,Body Temperature Regulations,Heat Losses,Loss, Heat,Losses, Heat,Regulations, Body Temperature,Temperature Regulations, Body,Thermoregulations
D004734	Energy Metabolism	The chemical reactions involved in the production and utilization of various forms of energy in cells.	Bioenergetics,Energy Expenditure,Bioenergetic,Energy Expenditures,Energy Metabolisms,Expenditure, Energy,Expenditures, Energy,Metabolism, Energy,Metabolisms, Energy
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012881	Skin Temperature	The TEMPERATURE at the outer surface of the body.	Skin Temperatures,Temperature, Skin,Temperatures, Skin
D013696	Temperature	The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.	Temperatures