[Bacteriological and clinical studies on metronidazole in Bacteroides fragilis infections (author's transl)]. 1979

K Shimada, and T Inamatsu, and K Sato

The antimicrobial activity of 24 Bacteroides fragilis, 13 Bacteroides thetaiotaomicron and 5 Bacteroides vulgatus, all of which were recent clinical isolates, was determined by the agar dilution technique. These three species had similar susceptibility patterns, but the B. thetaiotaomicron strains were generally less susceptible than the B. fragilis strains. Clindamycin was very active against 81% of the Bacteroides strains at 3.1 mcg/ml of less while 21% of the Bacteroides strains had MICs of 100 mcg/ml or above. Metronidazole was active against all Bacteroides strains at 1.6 mcg/ml or less. The patients with decubitus ulcers and B. fragilis septicemia, who responded satisfactorily to the combination of metronidazole and tobramycin, were presented.

UI MeSH Term Description Entries
D008297 Male Males
D008795 Metronidazole A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS. 2-Methyl-5-nitroimidazole-1-ethanol,Bayer 5360,Clont,Danizol,Flagyl,Gineflavir,Metric,MetroGel,Metrodzhil,Metrogyl,Metronidazole Hydrochloride,Metronidazole Monohydrochloride,Metronidazole Phosphate,Metronidazole Phosphoester,Satric,Trichazol,Trichopol,Trivazol,Vagilen,2 Methyl 5 nitroimidazole 1 ethanol
D004352 Drug Resistance, Microbial The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS). Antibiotic Resistance,Antibiotic Resistance, Microbial,Antimicrobial Resistance, Drug,Antimicrobial Drug Resistance,Antimicrobial Drug Resistances,Antimicrobial Resistances, Drug,Drug Antimicrobial Resistance,Drug Antimicrobial Resistances,Drug Resistances, Microbial,Resistance, Antibiotic,Resistance, Drug Antimicrobial,Resistances, Drug Antimicrobial
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D001441 Bacteroides fragilis Gram-negative bacteria occurring in the lower intestinal tracts of man and other animals. It is the most common species of anaerobic bacteria isolated from human soft tissue infections.
D001442 Bacteroides Infections Infections with bacteria of the genus BACTEROIDES. Infections, Bacteroides,Bacteroides Infection,Infection, Bacteroides

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