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The clinical effects of apalcillin (APPC) treatment for 7 patients with bile duct infections were investigated and the following results were obtained. 1) Clinical effectiveness: Of 7 patients treated with APPC, the results were good in 5 cases, fair in 1 case and poor in 1 case. 2) Absorption and excretion of APPC: One g of APPC was administered with one shot intravenously to 4 patients of which 2 were malignant tumor cases and the remaining 2 non tumor cases. A peak of APPC level in serum and bile was 79 microgram/ml and 140 microgram/ml respectively in malignant tumor cases and 96 microgram/ml and 180 microgram/ml respectively in non tumor cases. 3) Side effects of APPC: No significant side effects were observed in 7 patients treated with APPC, except abnormal elevation of S-GOT and S-GPT levels occurred transiently in 2 of 7 cases.
T Hirayama, and
K Kikuchi
September 1979,
The Japanese journal of antibiotics,
T Hirayama, and
K Kikuchi
February 1974,
The Japanese journal of antibiotics,
T Hirayama, and
K Kikuchi
October 1979,
The Japanese journal of antibiotics,
T Hirayama, and
K Kikuchi
July 1977,
[Hokkaido igaku zasshi] The Hokkaido journal of medical science,
T Hirayama, and
K Kikuchi
January 1980,
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
T Hirayama, and
K Kikuchi
August 1976,
Casopis lekaru ceskych,
T Hirayama, and
K Kikuchi
April 1977,
Casopis lekaru ceskych,
T Hirayama, and
K Kikuchi
August 1979,
The Japanese journal of antibiotics,
T Hirayama, and
K Kikuchi
October 1980,
Rinsho hoshasen. Clinical radiography,
