Biomaterial Database

Adrenoceptor functions in the cat choledochoduodenal junction in vitro. 1971

C G Persson

1. The effects of alpha- and beta-adrenoceptor stimulating agents were investigated on three different kinds of preparation of the isolated sphincter of Oddi and on the duodenum of the cat.2. Adrenaline (1.5 x 10(-7)M-6.3 x 10(-7)M), noradrenaline (1.6 x 10(-7)M-6.3 x 10(-7)M), and tyramine (2.9 x 10(-6)M-5.8 x 10(-6)M) increased the activity and tonus of the sphincter musculature and decreased duodenal activity and tone. The effect on the sphincter resulted in increased resistance to flow through the sphincter. The excitatory effects on the sphincter were blocked by phenoxybenzamine (1.7 x 10(-8)M-1.7 x 10(-7)M).3. No effect was produced by tyramine in concentrations up to 4.6 x 10(-5)M on sphincters taken from reserpinized cats. It is suggested that the cat sphincter of Oddi contains adrenergic nerves of functional importance.4. Isoprenaline (1.9 x 10(-8)M-4.7 x 10(-7)M) and terbutaline (3.5 x 10(-7)M-8.8 x 10(-6)M) decreased spontaneous activity and tonus of the sphincter, and diminished resistance to flow through the sphincter. Both agents decreased spontaneous activity and tonus of the duodenum. On a molar basis, isoprenaline was 2-18 times more active than terbutaline on the sphincter and 35-90 times more active on the duodenum. The effects of isoprenaline and terbutaline were blocked by propranolol (3.9 x 10(-7)M).5. It is concluded that the cat sphincter of Oddi contains alpha-adrenoceptors active in contraction of the sphincter, and beta-adrenoceptors active in its relaxation. The beta-adrenoceptors of the sphincter differ from those in the duodenum; it is suggested that they belong to the beta(2)-group (according to Lands' classification).6. The automaticity of the isolated sphincter of Oddi resembled the sphincter activity recorded in vivo and is probably myogenic in nature, as it resisted treatment with phenoxybenzamine (1.7 x 10(-8)M-1.7 x 10(-7)M), atropine (1.4 x 10(-6)M-5.8 x 10(-6)M), hexamethonium (1.4 x 10(-5)M-1.1 x 10(-4)M) and tetrodotoxin (1 mug/ml). The activity of the sphincter has no propulsive function but prevents passage of fluid through the sphincter.

UI	MeSH Term	Description	Entries
D007545	Isoproterenol	Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.	Isoprenaline,Isopropylarterenol,4-(1-Hydroxy-2-((1-methylethyl)amino)ethyl)-1,2-benzenediol,Euspiran,Isadrin,Isadrine,Isopropyl Noradrenaline,Isopropylnoradrenaline,Isopropylnorepinephrine,Isoproterenol Hydrochloride,Isoproterenol Sulfate,Isuprel,Izadrin,Norisodrine,Novodrin,Hydrochloride, Isoproterenol,Noradrenaline, Isopropyl,Sulfate, Isoproterenol
D009638	Norepinephrine	Precursor of epinephrine that is secreted by the ADRENAL MEDULLA and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers, and of the diffuse projection system in the brain that arises from the LOCUS CERULEUS. It is also found in plants and is used pharmacologically as a sympathomimetic.	Levarterenol,Levonorepinephrine,Noradrenaline,Arterenol,Levonor,Levophed,Levophed Bitartrate,Noradrenaline Bitartrate,Noradrénaline tartrate renaudin,Norepinephrin d-Tartrate (1:1),Norepinephrine Bitartrate,Norepinephrine Hydrochloride,Norepinephrine Hydrochloride, (+)-Isomer,Norepinephrine Hydrochloride, (+,-)-Isomer,Norepinephrine d-Tartrate (1:1),Norepinephrine l-Tartrate (1:1),Norepinephrine l-Tartrate (1:1), (+,-)-Isomer,Norepinephrine l-Tartrate (1:1), Monohydrate,Norepinephrine l-Tartrate (1:1), Monohydrate, (+)-Isomer,Norepinephrine l-Tartrate (1:2),Norepinephrine l-Tartrate, (+)-Isomer,Norepinephrine, (+)-Isomer,Norepinephrine, (+,-)-Isomer
D010643	Phenoxybenzamine	An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator.	Dibenylene,Dibenyline,Dibenziran,Dibenzylin,Dibenzyline,Dibenzyran,Phenoxybenzamine Hydrochloride,Hydrochloride, Phenoxybenzamine
D011941	Receptors, Adrenergic	Cell-surface proteins that bind epinephrine and/or norepinephrine with high affinity and trigger intracellular changes. The two major classes of adrenergic receptors, alpha and beta, were originally discriminated based on their cellular actions but now are distinguished by their relative affinity for characteristic synthetic ligands. Adrenergic receptors may also be classified according to the subtypes of G-proteins with which they bind; this scheme does not respect the alpha-beta distinction.	Adrenergic Receptors,Adrenoceptor,Adrenoceptors,Norepinephrine Receptor,Receptors, Epinephrine,Receptors, Norepinephrine,Adrenergic Receptor,Epinephrine Receptors,Norepinephrine Receptors,Receptor, Adrenergic,Receptor, Norepinephrine
D011955	Receptors, Drug	Proteins that bind specific drugs with high affinity and trigger intracellular changes influencing the behavior of cells. Drug receptors are generally thought to be receptors for some endogenous substance not otherwise specified.	Drug Receptors,Drug Receptor,Receptor, Drug
D012110	Reserpine	An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.	Raunervil,Raupasil,Rausedil,Rausedyl,Serpasil,Serpivite,V-Serp,V Serp
D012118	Resorcinols	A water-soluble crystalline benzene-1,3-diol (resorcinol) and its derivatives.	m-Dihydroxybenzenes,meta-Dihydroxybenzenes,m Dihydroxybenzenes,meta Dihydroxybenzenes
D002082	Butylamines	Isomeric amines of butane, where an amino group replaces a hydrogen on one of the four carbons. They include isobutylamine, n-Butylamine, sec-Butylamine, and tert-Butylamine.
D002415	Cats	The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)	Felis catus,Felis domesticus,Domestic Cats,Felis domestica,Felis sylvestris catus,Cat,Cat, Domestic,Cats, Domestic,Domestic Cat
D004386	Duodenum	The shortest and widest portion of the SMALL INTESTINE adjacent to the PYLORUS of the STOMACH. It is named for having the length equal to about the width of 12 fingers.	Duodenums