Biomaterial Database

A decongestant-antihistamine mixture in the prevention of otitis media in children with colds. 1979

J E Randall, and J O Hendley

One hundred four preschool-age patients in a private pediatric practice were treated prospectively during colds with either decongestant-antihistamine or placebo to determine if the decongestant-antihistamine mixture was effective in the prevention of otitis media. Each child received a standard dosage of the study medicine according to a double-blind, crossover design. Otitis media was diagnosed on the basis of clinical criteria. Fifteen (6.4%) of 234 colds treated with placebo and 14 (5.8%) of 241 colds treated with the study drug were followed by otitis. The decongestant-antihistamine mixture was not useful in preventing development of otitis media in children with colds.

UI	MeSH Term	Description	Entries
D007223	Infant	A child between 1 and 23 months of age.	Infants
D010033	Otitis Media	Inflammation of the MIDDLE EAR including the AUDITORY OSSICLES and the EUSTACHIAN TUBE.	Middle Ear Inflammation,Inflammation, Middle Ear
D010665	Phenylpropanolamine	A sympathomimetic that acts mainly by causing release of NOREPINEPHRINE but also has direct agonist activity at some adrenergic receptors. It is most commonly used as a nasal vasoconstrictor and an appetite depressant.	Norephedrine,Dexatrim,Phenylpropanolamine Hydrochloride,Prolamine,Propagest,Triaminic DM,Hydrochloride, Phenylpropanolamine
D011725	Pyridines	Compounds with a six membered aromatic ring containing NITROGEN. The saturated version is PIPERIDINES.
D001977	Brompheniramine	Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria.	p-Bromdylamine,para-Bromdylamine,Brompheniramine Maleate,Brompheniramine Maleate (1:1),Chlorphed,Dimetane,Dimetane-Ten,Dimetapp Allergy,Oraminic-2,Dimetane Ten,Maleate, Brompheniramine,Oraminic 2,p Bromdylamine,para Bromdylamine
D002675	Child, Preschool	A child between the ages of 2 and 5.	Children, Preschool,Preschool Child,Preschool Children
D003139	Common Cold	A catarrhal disorder of the upper respiratory tract, which may be viral or a mixed infection. It generally involves a runny nose, nasal congestion, and sneezing.	Cold, Common,Coryza, Acute,Catarrh,Acute Coryza,Catarrhs,Colds, Common,Common Colds
D004359	Drug Therapy, Combination	Therapy with two or more separate preparations given for a combined effect.	Combination Chemotherapy,Polychemotherapy,Chemotherapy, Combination,Combination Drug Therapy,Drug Polytherapy,Therapy, Combination Drug,Chemotherapies, Combination,Combination Chemotherapies,Combination Drug Therapies,Drug Polytherapies,Drug Therapies, Combination,Polychemotherapies,Polytherapies, Drug,Polytherapy, Drug,Therapies, Combination Drug
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man