Biomaterial Database

Cochlear neurons: frequency selectivity altered by perilymph removal. 1974

D Robertson

Removal of perilylmph from the scala tympani of the guinea pig cochlea reversibly broadened the tuning curves of single spiral ganglion cells emanating from the basilar membrane. Thus, fluid continuity along the membrane is essential for normal cochlear function, in particular for sharp neural tuning curves. These data reveal a possible source of error in some estimates of basilar membrane motion and suggest a reappraisal of current concepts of the mechanism of sharp tunig in primary auditory nerve fibers.

UI	MeSH Term	Description	Entries
D007761	Labyrinthine Fluids	Fluids found within the osseous labyrinth (PERILYMPH) and the membranous labyrinth (ENDOLYMPH) of the inner ear. (From Gray's Anatomy, 30th American ed, p1328, 1332)	Fluid, Labyrinthine,Fluids, Labyrinthine,Labyrinthine Fluid
D009474	Neurons	The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.	Nerve Cells,Cell, Nerve,Cells, Nerve,Nerve Cell,Neuron
D010498	Perilymph	The fluid separating the membranous labyrinth from the osseous labyrinth of the ear. It is entirely separate from the ENDOLYMPH which is contained in the membranous labyrinth. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1396, 642)	Perilymphs
D003051	Cochlea	The part of the inner ear (LABYRINTH) that is concerned with hearing. It forms the anterior part of the labyrinth, as a snail-like structure that is situated almost horizontally anterior to the VESTIBULAR LABYRINTH.	Cochleas
D006168	Guinea Pigs	A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.	Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D000161	Acoustic Stimulation	Use of sound to elicit a response in the nervous system.	Auditory Stimulation,Stimulation, Acoustic,Stimulation, Auditory
D000200	Action Potentials	Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.	Spike Potentials,Nerve Impulses,Action Potential,Impulse, Nerve,Impulses, Nerve,Nerve Impulse,Potential, Action,Potential, Spike,Potentials, Action,Potentials, Spike,Spike Potential
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001489	Basilar Membrane	A basement membrane in the cochlea that supports the hair cells of the ORGAN OF CORTI, consisting keratin-like fibrils. It stretches from the SPIRAL LAMINA to the basilar crest. The movement of fluid in the cochlea, induced by sound, causes displacement of the basilar membrane and subsequent stimulation of the attached hair cells which transform the mechanical signal into neural activity.	Basilar Membranes,Membrane, Basilar,Membranes, Basilar