BIOMAT Database Logo BIOMAT Database Logo

Cervical ripening prior to induction of labor (intracervical application of a PG E2 viscous gel). 1979

H Steiner, and H P Zahradnik, and M Breckwoldt, and D Robrecht, and H G Hillemanns

In 38 pregnant patients at term with unfavorable cervices labor induction was initiated with PG-E2 after a preceding intracervical application of 0.1, 0.2 or 0.3 mg PG-E2 in 1 ml viscous gel. The mean Bishop score improved from 3.36 to 7.0 in an average time of 2 h 37 min. The cervical diameter increased from 14 mm to 22.7 mm. 31 patients delivered their babies spontaneously, while 7 patients were delivered by cesarean section due to cervical dystocia and delayed labor. Fetal outcome was normal in all cases, with an average Apgar score of 8.7 and an average pH-value in the umbilical artery of 7.245. The study indicates that local application of PG-E2 induces cervical dilatation, and is of particular use in patients presenting a low Bishop score. A possible local effect of PG E2 is discussed.

UI MeSH Term Description Entries
D007751 Labor, Induced Artificially induced UTERINE CONTRACTION. Induced Labor,Induction of Labor,Labor Induced,Labor Induction,Induced, Labor,Induction, Labor,Inductions, Labor,Labor Inductions
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D011458 Prostaglandins E (11 alpha,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid (PGE(1)); (5Z,11 alpha,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid (PGE(2)); and (5Z,11 alpha,13E,15S,17Z)-11,15-dihydroxy-9-oxoprosta-5,13,17-trien-1-oic acid (PGE(3)). Three of the six naturally occurring prostaglandins. They are considered primary in that no one is derived from another in living organisms. Originally isolated from sheep seminal fluid and vesicles, they are found in many organs and tissues and play a major role in mediating various physiological activities. PGE
D002581 Uterine Cervical Incompetence Incompetent UTERINE CERVIX is usually diagnosed in the second trimester of PREGNANCY. It is characterized by passive painless cervical dilation in the absence of UTERINE CONTRACTION; BLEEDING; INFECTION; and sometimes with the amniotic sac (AMNIOTIC MEMBRANE) bulging through the partially dilated cervix. Left untreated, this condition may lead to premature pregnancy loss, such as HABITUAL ABORTION. Cervix Incompetence,Incompetent Cervix,Cervical Incompetence, Uterine,Cervices, Incompetent,Cervix, Incompetent,Incompetence, Cervix,Incompetence, Uterine Cervical,Incompetent Cervices
D004107 Dilatation and Curettage Dilatation of the cervix uteri followed by a scraping of the endometrium with a curette. Curettage and Dilatation,Dilatation & Curettage
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004341 Drug Evaluation Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals. Evaluation Studies, Drug,Drug Evaluation Studies,Drug Evaluation Study,Drug Evaluations,Evaluation Study, Drug,Evaluation, Drug,Evaluations, Drug,Studies, Drug Evaluation,Study, Drug Evaluation
D005260 Female Females
D005782 Gels Colloids with a solid continuous phase and liquid as the dispersed phase; gels may be unstable when, due to temperature or other cause, the solid phase liquefies; the resulting colloid is called a sol.
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

H Steiner, and H P Zahradnik, and M Breckwoldt, and D Robrecht, and H G Hillemanns
Intracervical prostaglandin E2 gel. Safety for outpatient cervical ripening before induction of labor.
August 1992, The Journal of reproductive medicine,
H Steiner, and H P Zahradnik, and M Breckwoldt, and D Robrecht, and H G Hillemanns
Induction of labor and cervical ripening by intracervical prostaglandin E2.
January 1985, Obstetrics and gynecology,
H Steiner, and H P Zahradnik, and M Breckwoldt, and D Robrecht, and H G Hillemanns
Intracervical prostaglandin E2 gel for cervical ripening and labor induction: what is the appropriate dose?
January 1993, Gynecologic and obstetric investigation,
H Steiner, and H P Zahradnik, and M Breckwoldt, and D Robrecht, and H G Hillemanns
Intracervical prostaglandin E2 gel for cervical ripening.
January 1987, Annales chirurgiae et gynaecologiae. Supplementum,
H Steiner, and H P Zahradnik, and M Breckwoldt, and D Robrecht, and H G Hillemanns
Cervical ripening and labor induction with intracervical triacetin base prostaglandin E2 gel: a placebo-controlled study.
October 1984, Obstetrics and gynecology,
H Steiner, and H P Zahradnik, and M Breckwoldt, and D Robrecht, and H G Hillemanns
Cervical ripening and labor outcome with preinduction intracervical prostaglandin E2 (Prepidil) gel.
January 1987, Journal of perinatology : official journal of the California Perinatal Association,
H Steiner, and H P Zahradnik, and M Breckwoldt, and D Robrecht, and H G Hillemanns
Ripening of the cervix and induction of labor in patients at term by single intracervical application of prostaglandin E2 in viscous gel.
January 1979, Acta obstetricia et gynecologica Scandinavica. Supplement,
H Steiner, and H P Zahradnik, and M Breckwoldt, and D Robrecht, and H G Hillemanns
Cervical ripening and induction of labor by prostaglandin E2: a comparison between intracervical gel and vaginal pessary.
September 2003, The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians,
H Steiner, and H P Zahradnik, and M Breckwoldt, and D Robrecht, and H G Hillemanns
Preinduction cervical ripening with prostaglandin E2 intracervical gel.
July 1986, Obstetrics and gynecology,
H Steiner, and H P Zahradnik, and M Breckwoldt, and D Robrecht, and H G Hillemanns
Pre-induction cervical ripening with prostaglandin E2 gel: intracervical versus intravaginal route.
October 1990, Obstetrics and gynecology,
Copied contents to your clipboard!