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Interaction between human C1q and IgG coated latex particles has been studied by means of a standard aggregometer equipment. A dose-dependent agglutination was observed and 100 ng of C1q were readily detected. The kinetics of the agglutination was also monitored. Serum, partially purified C1, and high molecular weight fractions from Sephadex G-200 fractionated serum produced agglutination only in the presence of EDTA. In the absence of this chelator these products disintegrated preformed C1q-IgG-latex particle agglutinates. This disagglutinating principle is heat-sensitive and tentatively macromolecular C1 dependent. The most probable basis of the activity is the competition between C1, with a high affinity for IgG particles, and C1q. The inability of C1 to induce particle agglutination might be caused by the C1 subunits C1r and C1s sterically inhibiting the subunit C1q to bridge between the particles.
R Hällgren, and
G Stålenheim, and
P Venge
November 1979,
FEBS letters,
R Hällgren, and
G Stålenheim, and
P Venge
April 1965,
Technical bulletin of the Registry of Medical Technologists. American Society of Clinical Pathologists. Registry of Medical Technologists,
R Hällgren, and
G Stålenheim, and
P Venge
July 1984,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
R Hällgren, and
G Stålenheim, and
P Venge
May 1989,
Zhonghua Minguo wei sheng wu ji mian yi xue za zhi = Chinese journal of microbiology and immunology,
R Hällgren, and
G Stålenheim, and
P Venge
April 1981,
Clinical and experimental immunology,
R Hällgren, and
G Stålenheim, and
P Venge
December 1990,
Journal of immunological methods,
R Hällgren, and
G Stålenheim, and
P Venge
January 1979,
Scandinavian journal of immunology,
R Hällgren, and
G Stålenheim, and
P Venge
September 1963,
American journal of clinical pathology,
R Hällgren, and
G Stålenheim, and
P Venge
March 1983,
Experimental eye research,
R Hällgren, and
G Stålenheim, and
P Venge
April 1979,
Journal of the Reticuloendothelial Society,
