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The effect of orotic acid on the development of compensatory pulmonary hypertrophy has been studied in the clinic and in the experiments (71 patients, and 349 rats) carried out with the use of morphologic, biochemical cytochemical, immunologic and clinical methods, and also through autoradiography. The results of the study prove the effect of the drug upon the pulmonary regeneration. Experimental findings have shown that behind the stimulating effect of the drug there is the activation of the synthesis of nucleinic acids, the rise of the mitotic activity of the interalveolar membranes cells of the lung remnants. An essential increase of the lymphocytic dehydrogenase activity of the peripheral blood occurred in response to the effect of the drug.
G L Bilich, and
E A Zagaĭnov, and
V N Otmakhov, and
L V Nazarova, and
E V Sungurova
March 1978,
Vestnik khirurgii imeni I. I. Grekova,
G L Bilich, and
E A Zagaĭnov, and
V N Otmakhov, and
L V Nazarova, and
E V Sungurova
June 1979,
Arkhiv anatomii, gistologii i embriologii,
G L Bilich, and
E A Zagaĭnov, and
V N Otmakhov, and
L V Nazarova, and
E V Sungurova
June 1993,
Carcinogenesis,
G L Bilich, and
E A Zagaĭnov, and
V N Otmakhov, and
L V Nazarova, and
E V Sungurova
January 1973,
Patologicheskaia fiziologiia i eksperimental'naia terapiia,
G L Bilich, and
E A Zagaĭnov, and
V N Otmakhov, and
L V Nazarova, and
E V Sungurova
April 1963,
The Journal of nutrition,
G L Bilich, and
E A Zagaĭnov, and
V N Otmakhov, and
L V Nazarova, and
E V Sungurova
November 1965,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
G L Bilich, and
E A Zagaĭnov, and
V N Otmakhov, and
L V Nazarova, and
E V Sungurova
June 1975,
Japanese journal of pharmacology,
G L Bilich, and
E A Zagaĭnov, and
V N Otmakhov, and
L V Nazarova, and
E V Sungurova
May 1965,
Minerva ginecologica,
G L Bilich, and
E A Zagaĭnov, and
V N Otmakhov, and
L V Nazarova, and
E V Sungurova
January 1969,
Farmakologiia i toksikologiia,
G L Bilich, and
E A Zagaĭnov, and
V N Otmakhov, and
L V Nazarova, and
E V Sungurova
August 1965,
Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association,
