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The effect of levamisole on the in vitro responses of splenic and peripheral blood lymphocytes to phytohemagglutinin were investigated in zinc-deprived and pair-fed control rats. The in vitro response of lymphocytes from zinc-deprived rats was markedly impaired in comparison with that of controls. The addition of levamisole to cultures of zinc-deprived splenic lymphocytes significantly improved their response to phytohemagglutinin by 54%. The addition of levamisole to cultures of zinc-deprived peripheral blood lymphocytes significantly improved their response by 116.2%. The addition of levamisole to control lymphocyte culture had no effect. This study may be the first to evaluate the beneficial effect of an immunomodulating agent on immune function in a nutritionally deprived host.
R L Gross, and
N Osdin, and
L Fong, and
P M Newberne
January 1979,
Developmental and comparative immunology,
R L Gross, and
N Osdin, and
L Fong, and
P M Newberne
September 1979,
Transplantation proceedings,
R L Gross, and
N Osdin, and
L Fong, and
P M Newberne
September 1992,
Physiology & behavior,
R L Gross, and
N Osdin, and
L Fong, and
P M Newberne
February 1964,
Blood,
R L Gross, and
N Osdin, and
L Fong, and
P M Newberne
April 1975,
Lancet (London, England),
R L Gross, and
N Osdin, and
L Fong, and
P M Newberne
January 1984,
Zeitschrift fur Parasitenkunde (Berlin, Germany),
R L Gross, and
N Osdin, and
L Fong, and
P M Newberne
January 1988,
Neoplasma,
R L Gross, and
N Osdin, and
L Fong, and
P M Newberne
October 1983,
Transplantation,
R L Gross, and
N Osdin, and
L Fong, and
P M Newberne
December 1981,
Immunopharmacology,
R L Gross, and
N Osdin, and
L Fong, and
P M Newberne
December 1982,
The Journal of laboratory and clinical medicine,
