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The method of the penetrating ions allows to observe the creatine phosphokinase function of heart mitochondria in steady state conditions. The addition of ADP to respiring mitochondria decreases the membrane potential in the course of the ATP synthesis. The subsequent addition of creatine decreases the membrane potential for a long period of time because of ADP formation in creatine phosphokinase reaction. It was shown in the experiments with maintainance of the constant concentration of ADP or ATP in the medium that the ADP concentration in the medium acts mainly on the membrane potential during the creatine phosphate synthesis. There is no effect of creatine on the membrane potential of liver mitochondria which have no creatine phosphokinase.
E A Liberman, and
G I Khachatrian, and
L M Tsofina
March 1984,
Archives of biochemistry and biophysics,
E A Liberman, and
G I Khachatrian, and
L M Tsofina
January 1977,
Nauchnye doklady vysshei shkoly. Biologicheskie nauki,
E A Liberman, and
G I Khachatrian, and
L M Tsofina
January 1973,
Biokhimiia (Moscow, Russia),
E A Liberman, and
G I Khachatrian, and
L M Tsofina
February 1983,
Die Pharmazie,
E A Liberman, and
G I Khachatrian, and
L M Tsofina
May 1997,
Biochimica et biophysica acta,
E A Liberman, and
G I Khachatrian, and
L M Tsofina
December 1979,
Journal of molecular and cellular cardiology,
E A Liberman, and
G I Khachatrian, and
L M Tsofina
March 1998,
British journal of pharmacology,
E A Liberman, and
G I Khachatrian, and
L M Tsofina
July 1970,
European journal of biochemistry,
E A Liberman, and
G I Khachatrian, and
L M Tsofina
July 2003,
Organic letters,
E A Liberman, and
G I Khachatrian, and
L M Tsofina
January 2013,
Ukrains'kyi biokhimichnyi zhurnal (1999 ),
