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Fifty depressed in-patients at two psychiatric units, one in Italy the other in England, were treated with clomipramine, either orally, or intravenously and orally. A comparison of clinical response with plasma levels of clomipramine and its metabolite, desmethylclomipramine, showed clear relationships especially in the case of desmethylclomipramine. In the intravenously-treated group this was linear, in the orally-treated group it was curvilinear. Plasma levels of desmethylclomipramine and administered clomipramine correlate highly. These findings, together with the fact that significant clinical improvement was observed in only 55% of the patients, suggest that titration of the administered dose to obtain more effective plasma levels of the metabolite might improve the clinical response to the drug in some patients.
L Della Corte, and
A D Broadhurst, and
G P Sgaragli, and
S Filippini, and
A F Heeley, and
H D James, and
C Faravelli, and
A Pazzagli
February 1984,
Journal of affective disorders,
L Della Corte, and
A D Broadhurst, and
G P Sgaragli, and
S Filippini, and
A F Heeley, and
H D James, and
C Faravelli, and
A Pazzagli
January 1980,
The Journal of international medical research,
L Della Corte, and
A D Broadhurst, and
G P Sgaragli, and
S Filippini, and
A F Heeley, and
H D James, and
C Faravelli, and
A Pazzagli
September 2003,
Journal of pharmacological sciences,
L Della Corte, and
A D Broadhurst, and
G P Sgaragli, and
S Filippini, and
A F Heeley, and
H D James, and
C Faravelli, and
A Pazzagli
August 1990,
Journal of clinical psychopharmacology,
L Della Corte, and
A D Broadhurst, and
G P Sgaragli, and
S Filippini, and
A F Heeley, and
H D James, and
C Faravelli, and
A Pazzagli
January 1979,
Communications in psychopharmacology,
L Della Corte, and
A D Broadhurst, and
G P Sgaragli, and
S Filippini, and
A F Heeley, and
H D James, and
C Faravelli, and
A Pazzagli
June 1982,
Journal of affective disorders,
L Della Corte, and
A D Broadhurst, and
G P Sgaragli, and
S Filippini, and
A F Heeley, and
H D James, and
C Faravelli, and
A Pazzagli
January 1982,
Journal de pharmacologie,
L Della Corte, and
A D Broadhurst, and
G P Sgaragli, and
S Filippini, and
A F Heeley, and
H D James, and
C Faravelli, and
A Pazzagli
September 1967,
Life sciences,
L Della Corte, and
A D Broadhurst, and
G P Sgaragli, and
S Filippini, and
A F Heeley, and
H D James, and
C Faravelli, and
A Pazzagli
November 1975,
Clinical pharmacology and therapeutics,
L Della Corte, and
A D Broadhurst, and
G P Sgaragli, and
S Filippini, and
A F Heeley, and
H D James, and
C Faravelli, and
A Pazzagli
November 1979,
Psychosomatics,
