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The interaction of Ca2+ with Morris hepatoma 3924A mitochondria and its effect on the adenine nucleotide translocation have been studied. The characteristics of the Ca2+ transport process in mitochondria from Morris hepatoma are not significantly different from those of normal liver mitochondria. The Km for Ca2+ is 2 to 3 microM, and the rate versus concentration curve exhibits hyperbolic kinetics. A lower activity of the adenine nucleotide translocation was found, probably due to the high endogenous Ca2+ content of Morris hepatoma mitochondria (123 +/- 15 nmol Ca2+ per mg protein). No further inhibition of the translocase activity was observed after isolated mitochondria had accumulated extra amounts of Ca2+. The total amount of adenine nucleotides in tumor mitochondria is one-half those present in control liver, and a significantly lower percentage of the pool is present as adenosine 5'-monophosphate.
M L Eboli, and
K Malmström, and
T Galeotti, and
L López-Alarcón, and
E Carafoli
December 1977,
Cancer research,
M L Eboli, and
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L López-Alarcón, and
E Carafoli
January 1966,
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M L Eboli, and
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M L Eboli, and
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Cancer research,
M L Eboli, and
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M L Eboli, and
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M L Eboli, and
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E Carafoli
April 1989,
FEBS letters,
M L Eboli, and
K Malmström, and
T Galeotti, and
L López-Alarcón, and
E Carafoli
April 1984,
FEBS letters,
M L Eboli, and
K Malmström, and
T Galeotti, and
L López-Alarcón, and
E Carafoli
December 1989,
Cancer research,
