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The effect of intraduodenal acid on pentagastrin-stimulated gastric secretion has been investigated in 12 normal subjects and 23 patients with chronic duodenal ulceration. Plasma secretin levels were monitored during each test using a highly sensitive radioimmunoassay. Significant inhibition of gastric secretion occurred in the normal subjects and duodenal ulcer patients. A significant rise in plasma secretin was observed in both groups after intraduodenal acid though there was a complete lack of correlation between the magnitude of the secretin response and the degree of gastric inhibition. Ten subjects received intraduodenal acid and a subsequent intravenous infusion of exogenous secretin (0.125-0.25 units/kg over six minutes). Gastric inhibition occurred after the acid instillation but not after secretin infusion despite plasma secretin levels greatly in excess of those produced by intraduodenal acid. These results suggest that release of secretin by itself cannot explain the gastric inhibitory response to intraduodenal acid in man.
A S Ward, and
S R Bloom
March 1992,
Digestive diseases and sciences,
A S Ward, and
S R Bloom
July 1964,
Gastroenterology,
A S Ward, and
S R Bloom
September 1974,
The British journal of surgery,
A S Ward, and
S R Bloom
August 1982,
The American journal of physiology,
A S Ward, and
S R Bloom
January 1990,
Digestion,
A S Ward, and
S R Bloom
November 1969,
The American journal of physiology,
A S Ward, and
S R Bloom
March 1971,
The American journal of digestive diseases,
A S Ward, and
S R Bloom
January 1981,
Scandinavian journal of gastroenterology,
A S Ward, and
S R Bloom
January 1997,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
A S Ward, and
S R Bloom
December 1994,
Gastroenterology,
