Biomaterial Database

Effect of swimming on reinnervation of rat skeletal muscle. 1974

G J Herbison, and M M Jaweed, and J F Ditunno

There are no studies that define the optimum intensity or time to begin exercising reinnervating muscle. Through overwork of reinnervating muscle, accomplished by synergistic tenotomy, we developed a working hypothesis. This hypothesis was tested on a physiological model. In the present study, the sciatic nerve of five groups of rats was crushed. One group served as the control and the remaining animals were exercised by swimming with weights attached to their tails for one or two hours each day (early reinnervation group) or four weeks (late reinnervating group) after crush denervation. The evaluation of muscle weights, fibre types, and protein concentration indicate that intense swimming (two hours every day) does not enhance the repair of reinnervation muscle. An evaluation of total proteins suggests that a high workload may be hazardous in the early phase of reinnervation. This study tends to confirm the hypothesis that when there are too few contractile units, as presumably is the case in early reinnervation, exercise inhibits the reinnervation process.

UI	MeSH Term	Description	Entries
D009121	Muscle Denervation	The resection or removal of the innervation of a muscle or muscle tissue.	Denervation, Muscle,Denervations, Muscle,Muscle Denervations
D009124	Muscle Proteins	The protein constituents of muscle, the major ones being ACTINS and MYOSINS. More than a dozen accessory proteins exist including TROPONIN; TROPOMYOSIN; and DYSTROPHIN.	Muscle Protein,Protein, Muscle,Proteins, Muscle
D009132	Muscles	Contractile tissue that produces movement in animals.	Muscle Tissue,Muscle,Muscle Tissues,Tissue, Muscle,Tissues, Muscle
D009210	Myofibrils	The long cylindrical contractile organelles of STRIATED MUSCLE cells composed of ACTIN FILAMENTS; MYOSIN filaments; and other proteins organized in arrays of repeating units called SARCOMERES .	Myofilaments,Myofibril,Myofilament
D009409	Nerve Crush	Treatment of muscles and nerves under pressure as a result of crush injuries.	Crush, Nerve
D009416	Nerve Regeneration	Renewal or physiological repair of damaged nerve tissue.	Nerve Tissue Regeneration,Nervous Tissue Regeneration,Neural Tissue Regeneration,Nerve Tissue Regenerations,Nervous Tissue Regenerations,Neural Tissue Regenerations,Regeneration, Nerve,Regeneration, Nerve Tissue,Regeneration, Nervous Tissue,Regeneration, Neural Tissue,Tissue Regeneration, Nerve,Tissue Regeneration, Nervous,Tissue Regeneration, Neural
D009929	Organ Size	The measurement of an organ in volume, mass, or heaviness.	Organ Volume,Organ Weight,Size, Organ,Weight, Organ
D001835	Body Weight	The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	Body Weights,Weight, Body,Weights, Body
D005082	Physical Exertion	Expenditure of energy during PHYSICAL ACTIVITY. Intensity of exertion may be measured by rate of OXYGEN CONSUMPTION; HEAT produced, or HEART RATE. Perceived exertion, a psychological measure of exertion, is included.	Physical Effort,Effort, Physical,Efforts, Physical,Exertion, Physical,Exertions, Physical,Physical Efforts,Physical Exertions
D005260	Female		Females