Biomaterial Database

Experimental study of measurement of regional bone blood flow in the adult mongrel dog using radioactive microspheres. 1979

M Okubo, and T Kinoshita, and T Yukimura, and Y Abe, and A Shimazu

To date, no one has conclusively accurately measured the regional bone blood flow mainly due to the lack of a proper investigative method. In this study, regional blood flow in the femur and tibia in adult mongrel dogs were studied using 85Sr-and 141Ce-labeled microspheres with a diameter of 15 +/- 5 microns. The blood flow rates were calculated by relating the radioactivity from tissue samples that from sample blood with a known flow. The highest rate of blood flow, 48.7 ml/min/100 g, was found in the femoral marrow and the lowest, 3.0 ml/min/100 g, in the diaphyseal cortex of the tibia. Flow rates in the metaphyseal regions, about 15 or 20 ml/min/100 g, were one and a half or 2 times greater than those in the epiphyseal regions. These values were mostly within the range of values reported by other investigators. Radioactive microspheres can be applied not only to physiological conditions but also to various pathological conditions if their size and the dose, the site and method of injection and tissue sampling are investigated further.

UI	MeSH Term	Description	Entries
D008863	Microspheres	Small uniformly-sized spherical particles, of micrometer dimensions, frequently labeled with radioisotopes or various reagents acting as tags or markers.	Latex Beads,Latex Particles,Latex Spheres,Microbeads,Bead, Latex,Beads, Latex,Latex Bead,Latex Particle,Latex Sphere,Microbead,Microsphere,Particle, Latex,Particles, Latex,Sphere, Latex,Spheres, Latex
D012039	Regional Blood Flow	The flow of BLOOD through or around an organ or region of the body.	Blood Flow, Regional,Blood Flows, Regional,Flow, Regional Blood,Flows, Regional Blood,Regional Blood Flows
D001775	Blood Circulation	The movement of the BLOOD as it is pumped through the CARDIOVASCULAR SYSTEM.	Blood Flow,Circulation, Blood,Blood Flows,Flow, Blood
D001842	Bone and Bones	A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principal cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.	Bone Tissue,Bone and Bone,Bone,Bones,Bones and Bone,Bones and Bone Tissue,Bony Apophyses,Bony Apophysis,Condyle,Apophyses, Bony,Apophysis, Bony,Bone Tissues,Condyles,Tissue, Bone,Tissues, Bone
D001853	Bone Marrow	The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.	Marrow,Red Marrow,Yellow Marrow,Marrow, Bone,Marrow, Red,Marrow, Yellow
D002565	Cerium Radioisotopes	Unstable isotopes of cerium that decay or disintegrate emitting radiation. Ce atoms with atomic weights 132-135, 137, 139, and 141-148 are radioactive cerium isotopes.	Radioisotopes, Cerium
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D005269	Femur	The longest and largest bone of the skeleton, it is situated between the hip and the knee.	Trochanter,Greater Trochanter,Lesser Trochanter,Femurs,Greater Trochanters,Lesser Trochanters,Trochanter, Greater,Trochanter, Lesser,Trochanters,Trochanters, Greater,Trochanters, Lesser
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013326	Strontium Radioisotopes	Unstable isotopes of strontium that decay or disintegrate spontaneously emitting radiation. Sr 80-83, 85, and 89-95 are radioactive strontium isotopes.	Radioisotopes, Strontium