-transparent.png){kind=logo}
Cephalothin kinetics was studied in 5 patients the day before (PREOP), during (SURG), and the day after (POSTOP) cardiopulmonary bypass surgery. The PREOP (114 ml/min) and SURG (94 ml/min) renal clearances were of the same order but both were less than POSTOP renal clearance (248 ml/min). Cephalothin total body clearance during operation was lower (p less than 0.01) than PREOP or POSTOP clearance, with decreased metabolic clearance the primary cause. There was reduction in cephalothin elimination throughout the surgical procedure, not only in the period of extracorporeal circulation, indicating that general anesthesia had a significant influence on drug disposition. The metabolite deacetylcephalothin was rapidly formed on all 3 days and its kinetic behavior paralleled that of the parent drug.
K W Miller, and
K K Chan, and
H G McCoy, and
R P Fischer, and
W G Lindsay, and
D E Zaske
January 1985,
International journal of clinical pharmacology research,
K W Miller, and
K K Chan, and
H G McCoy, and
R P Fischer, and
W G Lindsay, and
D E Zaske
February 1976,
The Journal of thoracic and cardiovascular surgery,
K W Miller, and
K K Chan, and
H G McCoy, and
R P Fischer, and
W G Lindsay, and
D E Zaske
January 1990,
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
K W Miller, and
K K Chan, and
H G McCoy, and
R P Fischer, and
W G Lindsay, and
D E Zaske
December 1981,
Clinical pharmacology and therapeutics,
K W Miller, and
K K Chan, and
H G McCoy, and
R P Fischer, and
W G Lindsay, and
D E Zaske
May 2003,
Perfusion,
K W Miller, and
K K Chan, and
H G McCoy, and
R P Fischer, and
W G Lindsay, and
D E Zaske
April 1978,
Clinical pharmacology and therapeutics,
K W Miller, and
K K Chan, and
H G McCoy, and
R P Fischer, and
W G Lindsay, and
D E Zaske
June 2006,
Collegium antropologicum,
K W Miller, and
K K Chan, and
H G McCoy, and
R P Fischer, and
W G Lindsay, and
D E Zaske
July 1983,
Antimicrobial agents and chemotherapy,
K W Miller, and
K K Chan, and
H G McCoy, and
R P Fischer, and
W G Lindsay, and
D E Zaske
December 1984,
The Journal of thoracic and cardiovascular surgery,
K W Miller, and
K K Chan, and
H G McCoy, and
R P Fischer, and
W G Lindsay, and
D E Zaske
August 2014,
Clinics (Sao Paulo, Brazil),
