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Therapy with phentolamine can improve the condition of patients with congestive heart failure due to the inotropic effect of this drug, as well as its vasodilating action. The use of oral therapy with phentolamine has not been adequately investigated in patients with chronic heart failure. Therefore, nine patients with chronic heart failure due to underlying valvular disease received 50 mg of phentolamine four times a day for two weeks. Echocardiograms and measurements of systolic time intervals were obtained prior to administration of phentolamine and two weeks after the introduction of therapy with the drug. As a result of therapy with phentolamine, the ejection fraction, the percentage of change in the minor axis, and the velocity of circumferential fiber shortening significantly increased, while the left atrial dimension decreased. Therapy with phentolamine produced a significant decrease in the preejection period index, as well as the ratio of the preejection period over the left ventricular ejection time. Thus, oral therapy with phentolamine improves left ventricular function in patients with chronic heart failure.
L A Gould, and
C V Reddy
June 1981,
Die Medizinische Welt,
L A Gould, and
C V Reddy
August 1983,
Drugs,
L A Gould, and
C V Reddy
January 1985,
Indian heart journal,
L A Gould, and
C V Reddy
July 1988,
The American journal of cardiology,
L A Gould, and
C V Reddy
January 1983,
Giornale italiano di cardiologia,
L A Gould, and
C V Reddy
June 1990,
Clinical cardiology,
L A Gould, and
C V Reddy
November 1987,
Klinische Wochenschrift,
L A Gould, and
C V Reddy
May 1981,
American heart journal,
L A Gould, and
C V Reddy
April 1968,
Revista espanola de cardiologia,
L A Gould, and
C V Reddy
February 1980,
Journal of the Medical Association of Georgia,
