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For studies on the lysosome-stabilizing effect of D-glucaric acid derivatives which have been found to have anti-inflammatory effect, the available and soluble enzyme activities of acid phosphatase of rat liver lysosomes were determined. Saliployed as standards. Lysosomes were incubated with drugs under specific conditions which allowed the data on the stabilizing activity of the drugs to be reproducible. The inhibitory effect of D-glucaro-1, 4-lactone, salicylic acid and phenylbutazone onover a wide range of concentrations. D-glucaro-1, 4-lactone as well as salicylic acid exhibited concentration-dependent lysosome-stabilizing effect whereas phenlybutazone had an optimum concentration for its lysosome-stabilizing effect. In addition, D-glucaro-1, 4-lactone,saliclicacid and phenylubtazone were also examined for their effects on heat-induced and saponin-induced hemolysis of rat erythrocyres. Both salicylic acid and phenylbutazone exhibited potent stabilziing and labilizing effects on heat-induced and saponin-induced hemolysis of eryhthrocytes, respectively. D-glucaro-1, 4-lactone, however, was incabale of affecting the hemolysis of erythrocytes. There appears to be a difference in the mechanism of the lysosome-stabilizing effects between D-glucaric acid derivatives and other anti-inflammatory drugs.
K Furuno, and
H Matsushita, and
R Nagashima, and
H Nakano, and
S Suzuki
October 1974,
Arzneimittel-Forschung,
K Furuno, and
H Matsushita, and
R Nagashima, and
H Nakano, and
S Suzuki
December 1968,
The Journal of endocrinology,
K Furuno, and
H Matsushita, and
R Nagashima, and
H Nakano, and
S Suzuki
January 1977,
Biochemical pharmacology,
K Furuno, and
H Matsushita, and
R Nagashima, and
H Nakano, and
S Suzuki
November 1977,
Bulletin of environmental contamination and toxicology,
K Furuno, and
H Matsushita, and
R Nagashima, and
H Nakano, and
S Suzuki
June 1974,
British journal of clinical pharmacology,
K Furuno, and
H Matsushita, and
R Nagashima, and
H Nakano, and
S Suzuki
October 1990,
Cancer letters,
K Furuno, and
H Matsushita, and
R Nagashima, and
H Nakano, and
S Suzuki
October 1982,
European journal of biochemistry,
K Furuno, and
H Matsushita, and
R Nagashima, and
H Nakano, and
S Suzuki
September 1969,
Toxicon : official journal of the International Society on Toxinology,
K Furuno, and
H Matsushita, and
R Nagashima, and
H Nakano, and
S Suzuki
January 1972,
Toxicon : official journal of the International Society on Toxinology,
K Furuno, and
H Matsushita, and
R Nagashima, and
H Nakano, and
S Suzuki
January 1970,
Doklady Akademii nauk SSSR,
