-transparent.png){kind=logo}
Near-normal glucose tolerance tests in diabetic dogs were obtained during basal rate insulin infusions in restrained animals by use of extracorporeal infusion pumps and in conscious, unrestrained animals by means of implanted infusion pumps. Even better regulation of blood glucose in diabetic animals was obtained by the addition of predetermined pulses of insulin at higher flow rates than the basal flow rate, accomplished by use of a transcutaneously activated valve mechanism attached to the implanted infusion pump. We conclude that near-normal blood glucose concentrations can be maintained throughout the day in the dog by these means and that similar approaches, using implantable infusion pumps, in man may lead to better long-term control of diabetes than is currently available.
P J Blackshear, and
T D Rohde, and
J C Grotting, and
F D Dorman, and
P R Perkins, and
R L Varco, and
H Buchwald
July 1984,
Diabetes research (Edinburgh, Scotland),
P J Blackshear, and
T D Rohde, and
J C Grotting, and
F D Dorman, and
P R Perkins, and
R L Varco, and
H Buchwald
January 2017,
PloS one,
P J Blackshear, and
T D Rohde, and
J C Grotting, and
F D Dorman, and
P R Perkins, and
R L Varco, and
H Buchwald
January 1986,
Diabetes research and clinical practice,
P J Blackshear, and
T D Rohde, and
J C Grotting, and
F D Dorman, and
P R Perkins, and
R L Varco, and
H Buchwald
January 1981,
Neurosurgery,
P J Blackshear, and
T D Rohde, and
J C Grotting, and
F D Dorman, and
P R Perkins, and
R L Varco, and
H Buchwald
January 1983,
Transactions - American Society for Artificial Internal Organs,
P J Blackshear, and
T D Rohde, and
J C Grotting, and
F D Dorman, and
P R Perkins, and
R L Varco, and
H Buchwald
April 2016,
Archives of disease in childhood. Education and practice edition,
P J Blackshear, and
T D Rohde, and
J C Grotting, and
F D Dorman, and
P R Perkins, and
R L Varco, and
H Buchwald
September 1974,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
P J Blackshear, and
T D Rohde, and
J C Grotting, and
F D Dorman, and
P R Perkins, and
R L Varco, and
H Buchwald
September 1982,
Diabetologia,
P J Blackshear, and
T D Rohde, and
J C Grotting, and
F D Dorman, and
P R Perkins, and
R L Varco, and
H Buchwald
January 1996,
The Annals of thoracic surgery,
P J Blackshear, and
T D Rohde, and
J C Grotting, and
F D Dorman, and
P R Perkins, and
R L Varco, and
H Buchwald
January 1999,
Diabetes technology & therapeutics,
