Biomaterial Database

[Histology of a plexiform neuroma with Vater-Pacini-lamellar-corpuscle-like structures]. 1979

P Altmeyer

From the finger of a 11 year old boy a tumor that had been present since birth was removed. Histological examination showed a great number of immature nerve bundles, and structures resembling Pacinian corpuscles. It could be shown that the organoid structures are a result of a proliferation of the so-called perineurial cells. These formations do not correspond with real tactile corpuscles, rather they can be considered as neoplastic structures of the perineurium.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009455	Neurofibroma	A moderately firm, benign, encapsulated tumor resulting from proliferation of SCHWANN CELLS and FIBROBLASTS that includes portions of nerve fibers. The tumors usually develop along peripheral or cranial nerves and are a central feature of NEUROFIBROMATOSIS 1, where they may occur intracranially or involve spinal roots. Pathologic features include fusiform enlargement of the involved nerve. Microscopic examination reveals a disorganized and loose cellular pattern with elongated nuclei intermixed with fibrous strands. (From Adams et al., Principles of Neurology, 6th ed, p1016)	Neurofibromas
D010141	Pacinian Corpuscles	Rapidly adapting mechanoreceptors found in subcutaneous tissue beneath both hairy and glabrous skin. Pacinian corpuscles contain an afferent nerve fiber surrounded by a capsule with multiple concentric layers. They have large receptive fields and are most sensitive to high-frequency stimuli, such as vibration.	Pacinian Corpuscle,Corpuscle, Pacinian,Corpuscles, Pacinian
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D005385	Fingers	Four or five slender jointed digits in humans and primates, attached to each HAND.	Finger
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012878	Skin Neoplasms	Tumors or cancer of the SKIN.	Cancer of Skin,Skin Cancer,Cancer of the Skin,Neoplasms, Skin,Cancer, Skin,Cancers, Skin,Neoplasm, Skin,Skin Cancers,Skin Neoplasm