Biomaterial Database

Tissue-specific incorporation of positional isomers of dietary cis- and trans-octadecenoic acids in the rat. 1979

I Reichwald-Hacker, and K Ilsemann, and K D Mukherjee

The total lipids of liver, heart, blood serum, adipose tissue, testes and adrenals of rats fed a partially hydrogenated fat were found to contain each of the dietary delta 5- to delta 15- cis- and delta 3- to delta 16- trans-octadecenoic acids. The pattern of incorporation of individual isomeric octadecenoic acids was found to be specific for the different tissues. trans-Isomers were preferentially incorporated into liver and heart, whereas cis-isomers were enriched in the testes. The composition of positional isomers of both cis- and trans-octadecenoic acids in adipose tissue, testes and adrenals was similar to that of the dietary lipids, whereas the corresponding compositions in liver, heart and serum were distinctly different. Thus, within the series of cis-octadecenoic acids, less oleic acid (delta 9-isomer) and correspondingly higher proportions of vaccenic acid (delta 11-isomer) were found in liver and heart than in the dietary lipids. Within the series of trans-octadecenoic acids, the isomers ranging from delta 12 to delta 16, especially the delta 14-isomer, were preferentially incorporated into liver, heart and serum, whereas the delta 10- and delta 11-isomers, were distinctly excluded from these tissues.

UI	MeSH Term	Description	Entries
D007536	Isomerism	The phenomenon whereby certain chemical compounds have structures that are different although the compounds possess the same elemental composition. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)	Isomerisms
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D008297	Male		Males
D009206	Myocardium	The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.	Muscle, Cardiac,Muscle, Heart,Cardiac Muscle,Myocardia,Cardiac Muscles,Heart Muscle,Heart Muscles,Muscles, Cardiac,Muscles, Heart
D009829	Oleic Acids	A group of fatty acids that contain 18 carbon atoms and a double bond at the omega 9 carbon.	Octadecenoic Acids,Acids, Octadecenoic,Acids, Oleic
D004041	Dietary Fats	Fats present in food, especially in animal products such as meat, meat products, butter, ghee. They are present in lower amounts in nuts, seeds, and avocados.	Fats, Dietary,Dietary Fat,Fat, Dietary
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013329	Structure-Activity Relationship	The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.	Relationship, Structure-Activity,Relationships, Structure-Activity,Structure Activity Relationship,Structure-Activity Relationships
D014018	Tissue Distribution	Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.	Distribution, Tissue,Distributions, Tissue,Tissue Distributions
D050356	Lipid Metabolism	Physiological processes in biosynthesis (anabolism) and degradation (catabolism) of LIPIDS.	Metabolism, Lipid