BIOMAT Database Logo BIOMAT Database Logo

Studies of amygdalin (laetrile) toxicity in rodents. 1979

J D Khandekar, and H Edelman

Amygdalin (laetrile), given to Fischer 344 rats in doses of 250, 500, and 750 mg/kg intraperitoneally daily for five days, caused mortalities of 30.8% 44.1%, and 56.8%, respectively. The mode of death and the elevated serum cyanide levels in the dying animals strongly suggested cyanide poisoning as the cause of death. These findings seriously question the use of amygdalin in clinical medicine under any circumstances.

UI MeSH Term Description Entries
D002279 Carcinoma 256, Walker A transplantable carcinoma of the rat that originally appeared spontaneously in the mammary gland of a pregnant albino rat, and which now resembles a carcinoma in young transplants and a sarcoma in older transplants. (Stedman, 25th ed) Carcinosarcoma 256, Walker,Walker Carcinoma 256,Walker Carcinosarcoma 256
D003486 Cyanides Inorganic salts of HYDROGEN CYANIDE containing the -CN radical. The concept also includes isocyanides. It is distinguished from NITRILES, which denotes organic compounds containing the -CN radical. Cyanide,Isocyanide,Isocyanides
D003520 Cyclophosphamide Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer. (+,-)-2-(bis(2-Chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-Oxide Monohydrate,B-518,Cyclophosphamide Anhydrous,Cyclophosphamide Monohydrate,Cyclophosphamide, (R)-Isomer,Cyclophosphamide, (S)-Isomer,Cyclophosphane,Cytophosphan,Cytophosphane,Cytoxan,Endoxan,NSC-26271,Neosar,Procytox,Sendoxan,B 518,B518,NSC 26271,NSC26271
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D000678 Amygdalin A cyanogenic glycoside found in the seeds of Rosaceae. Amygdaloside,Mandelonitrile-beta-Gentiobioside,Vitamin B17,Laetrile,Neoamygdalin,Mandelonitrile beta Gentiobioside
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012965 Sodium Chloride A ubiquitous sodium salt that is commonly used to season food. Sodium Chloride, (22)Na,Sodium Chloride, (24)NaCl
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

J D Khandekar, and H Edelman
Amygdalin (laetrile) toxicity in rodents.
June 1980, JAMA,
J D Khandekar, and H Edelman
Amygdalin (Laetrile) toxicity in rodents.
November 1979, JAMA,
J D Khandekar, and H Edelman
Amygdalin (laetrile).
July 1978, Kansas statutes annotated : duly arranged, numbered, annotated, and indexed with histories, notes, and references as required by law. Kansas,
J D Khandekar, and H Edelman
Amygdalin (laetrile).
January 1978, New Jersey statutes annotated : Permanent ed. Laws of a general and permanent nature under arrangement of Revised statutes, 1937, including laws of the 163rd Legislature, 1939; with annotations from cases construing or applying the laws...,
J D Khandekar, and H Edelman
Initial pharmacologic studies of amygdalin (laetrile) in man.
October 1978, Research communications in chemical pathology and pharmacology,
J D Khandekar, and H Edelman
Use of amygdalin (laetrile).
January 1977, Indiana code : comprising all laws of a general and permanent nature including statutes enacted through the 1982 regular session of the Indiana General Assembly. Indiana,
J D Khandekar, and H Edelman
Role of the gastrointestinal microflora in amygdalin (laetrile)-induced cyanide toxicity.
February 1980, Biochemical pharmacology,
J D Khandekar, and H Edelman
Amygdalin (Laetrile) and veterinary medicine.
August 1977, Journal of the American Veterinary Medical Association,
J D Khandekar, and H Edelman
Pharmaceutical assessment of amygdalin (Laetrile) products.
January 1978, Cancer treatment reports,
J D Khandekar, and H Edelman
Laetrile toxicity studies in dogs.
March 1978, JAMA,
Copied contents to your clipboard!