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Bacterial endocarditis was produced by intravenous injection of Streptococcus viridans into rabbits with preexisting sterile endocardial vegetations. After 6 h had elapsed, bacteria in the vegetations could not be eradicated by brief treatment with antimicrobials to which the streptococci were sensitive. However, when treatment with penicillin was continued for 4 days, the animals were cured. The 6-h infection therefore offered a model in which treatments could be conveniently compared over a short period. Synergism was demonstrated between penicillin and streptomycin in endocarditis due to a fully penicillin-sensitive streptococcus, a point which had not been previously proved in vivo. The clinical implications are discussed.
D T Durack, and
L L Pelletier, and
R G Petersdorf
March 1972,
The American journal of the medical sciences,
D T Durack, and
L L Pelletier, and
R G Petersdorf
August 1974,
Annals of internal medicine,
D T Durack, and
L L Pelletier, and
R G Petersdorf
September 1982,
Lancet (London, England),
D T Durack, and
L L Pelletier, and
R G Petersdorf
November 1982,
Lancet (London, England),
D T Durack, and
L L Pelletier, and
R G Petersdorf
December 1953,
British journal of experimental pathology,
D T Durack, and
L L Pelletier, and
R G Petersdorf
February 1961,
JAMA,
D T Durack, and
L L Pelletier, and
R G Petersdorf
February 1982,
Mayo Clinic proceedings,
D T Durack, and
L L Pelletier, and
R G Petersdorf
April 1979,
JAMA,
D T Durack, and
L L Pelletier, and
R G Petersdorf
November 1979,
Lancet (London, England),
D T Durack, and
L L Pelletier, and
R G Petersdorf
March 1962,
Science (New York, N.Y.),
