Storage, concentration and excretion of bile in the extrahepatic bile duct system are rather complicated processes being regulated by the autonomous nervous system. Groups of ganglionic cells and nerve fibers are located in the papilla, the neck of the gall bladder, and to a lesser degree in the wall of the gall bladder, that is to say in parts of the system which are important in regard to coordination of the excretory function. The number of ganglionic cells decreases in diseases which go along with functional disorders of the bile duct system. If the papilla Vateri and the duodenal musculature are disconnected anatomically, the papilla will retain autonomous muscular activity which however will not be coordinated any more with duodenal function, as the chymus passes by. Parasympathetic activity plays a major role in regulating the complicated mechanism of bile excretion. The autonomous nervous system is important for normal functioning not only of bile excretion but also of other organs; this explains the coincidence of dyskinesia of the bile ducts with other functional disorders being observed rather often. Autonomous regulation of bile excretion has to be taken into consideration as well, when it comes to outlining a therapeutic regimen.