Increasing the rate of ethanol consumption in food- and water-satiated rats. 1979

J S Macdonall, and H Marcucella

The effects of food satiation, ethanol concentration, and the schedule of ethanol availability on the rate of ethanol consumption were investigated in rats. In Experiment 1 separate groups were exposed to 6.2 or 12.5% w/v ethanol and unlimited access to food. The food and ethanol were available concurrently for one to three hours daily. After approximately 15 sessions unlimited food was available whenever ethanol was not available. The rate of ethanol consumption was positively related to ethanol concentration and negatively related to duration of ethanol availability. In Experiment 2 similar procedures were followed, except rats had unlimited access to food throughout the experiment. The results were similar to Experiment 1. In Experiment 3 separate groups were exposed to 6.2 and 12.5% w/v ethanol for one hour every other day; unlimited food was available throughout the experiment. The results were similar to the one-hour availability groups in Experiments 1 and 2. In all experiments ethanol consumption rates increased to levels above baseline and above the usual ethanol metabolic rate found in rats. The results demonstrated new combinations of ethanol availability and non-availability durations that were sufficient to significantly increase the rate of ethanol consumption.

UI MeSH Term Description Entries
D008297 Male Males
D005502 Food Substances taken in by the body to provide nourishment. Foods
D000428 Alcohol Drinking Behaviors associated with the ingesting of ALCOHOLIC BEVERAGES, including social drinking. Alcohol Consumption,Alcohol Intake,Drinking, Alcohol,Alcohol Drinking Habits,Alcohol Drinking Habit,Alcohol Intakes,Consumption, Alcohol,Drinking Habit, Alcohol,Habit, Alcohol Drinking,Habits, Alcohol Drinking,Intake, Alcohol
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012527 Satiation Full gratification of a need or desire followed by a state of relative insensitivity to that particular need or desire. Satiations
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor
D014867 Water A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Hydrogen Oxide
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

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