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Glucagon and insulin are first detectable at the onset of rat pancreas organogenesis. Initially, the specific activity of glucagon is approximately 100-fold higher than that of insulin. At this early stage, endocrine storage granules, similar to alpha granules, are identifiable in electron micrographs. The granule characteristics, as well as the relative hormone levels, suggest that the early population of differentiated endocrine cells is in fact composed of glucagon-producing (A) cells. This high level of glucagon is present in the embryo much earlier than the metabolic processes thought to be controlled by this hormone. Moreover, glucagon-producing cells may be the first endocrine cells to differentiate. Other known endocrine products accumulate later, during the terminal stages of organogenesis. These observations suggest that glucagon may have a regulatory function in early embryogenesis.
L B Rall, and
R L Pictet, and
R H Williams, and
W J Rutter
May 1997,
Nature,
L B Rall, and
R L Pictet, and
R H Williams, and
W J Rutter
August 2006,
Tissue engineering,
L B Rall, and
R L Pictet, and
R H Williams, and
W J Rutter
August 1981,
Proceedings of the National Academy of Sciences of the United States of America,
L B Rall, and
R L Pictet, and
R H Williams, and
W J Rutter
October 2005,
Diabetes,
L B Rall, and
R L Pictet, and
R H Williams, and
W J Rutter
November 2002,
Diabetes,
L B Rall, and
R L Pictet, and
R H Williams, and
W J Rutter
January 2006,
Nature protocols,
L B Rall, and
R L Pictet, and
R H Williams, and
W J Rutter
May 1976,
Indian journal of experimental biology,
L B Rall, and
R L Pictet, and
R H Williams, and
W J Rutter
January 1988,
Klinicheskaia khirurgiia,
L B Rall, and
R L Pictet, and
R H Williams, and
W J Rutter
March 1972,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
L B Rall, and
R L Pictet, and
R H Williams, and
W J Rutter
April 2010,
Pancreas,
