Biomaterial Database

Circadian rhythms of plasma corticosterone binding activity in the rat and the mouse. 1979

J E Ottenweller, and A H Meier, and A C Russo, and M E Frenzke

Corticosterone binding activity (CBA) and corticosteroids were measured by competitive protein binding techniques in plasma samples drawn from rats and mice at different times of day. Circacian rhythms of plasma CBA were found in both rats (onset of 14-h daily photoperiod: 0600) and mice (onset of 14-h daily photoperiod: 0700). The plasma CBA rhythm was bimodal in rats with peaks at 1000 and 1800 and unimodal in mice with peak level from 0100 to 0500. Circadian rhythms of plasma corticosteroid concentration with peaks during the late afternoon were confirmed in both rats and mice. The plasma CBA rhythms appear to be related to the circadian rhythms of both locomotor activity and plasma corticosteroid concentration.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D010828	Physiology, Comparative	The biological science concerned with similarities or differences in the life-supporting functions and processes of different species.	Comparative Physiology
D011485	Protein Binding	The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.	Plasma Protein Binding Capacity,Binding, Protein
D002940	Circadian Rhythm	The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs or environmental and physiological stimuli.	Diurnal Rhythm,Nyctohemeral Rhythm,Twenty-Four Hour Rhythm,Nycthemeral Rhythm,Circadian Rhythms,Diurnal Rhythms,Nycthemeral Rhythms,Nyctohemeral Rhythms,Rhythm, Circadian,Rhythm, Diurnal,Rhythm, Nycthemeral,Rhythm, Nyctohemeral,Rhythm, Twenty-Four Hour,Rhythms, Circadian,Rhythms, Diurnal,Rhythms, Nycthemeral,Rhythms, Nyctohemeral,Rhythms, Twenty-Four Hour,Twenty Four Hour Rhythm,Twenty-Four Hour Rhythms
D003345	Corticosterone	An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)
D004986	Ether	A mobile, very volatile, highly flammable liquid used as an inhalation anesthetic and as a solvent for waxes, fats, oils, perfumes, alkaloids, and gums. It is mildly irritating to skin and mucous membranes.	Diethyl Ether,Ether, Ethyl,Ethyl Ether,Ether, Diethyl
D005260	Female		Females
D000305	Adrenal Cortex Hormones	HORMONES produced by the ADRENAL CORTEX, including both steroid and peptide hormones. The major hormones produced are HYDROCORTISONE and ALDOSTERONE.	Adrenal Cortex Hormone,Corticoid,Corticoids,Corticosteroid,Corticosteroids,Cortex Hormone, Adrenal,Hormone, Adrenal Cortex,Hormones, Adrenal Cortex
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001667	Binding, Competitive	The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements.	Competitive Binding