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Since recent studies have indicated that measurement in urine of the amino acid, 3-methylhistidine, accurately reflects the extent of muscle catabolism, and because it has been suggested that thyroid hormones may influence muscle breakdown, especially during fasting, the effect of T3 and reverse T3 (rT3) administration on the excretion of 3-methylhistidine was examined in obese subjects during fasting. The mean (+/- SE) 3-methylhistidine excretion in patients fed an egg protein diet (devoid of meat protein) was 256 +/- 35 mumoles/day and decreased to 190 +/- 14 mumoles/day during fasting. T3 administration (100 microgram/day x 5 days) increased 3-methylhistidine excretion to 304 +/- 37 mumoles/day during its ingestion and to 485 +/- 46 mumoles/day in the T3 posttreatment interval. T3 doses of 10 microgram every 4 hr (q4h) for the first 6 days of fasting also appeared capable of increasing 3-mehis excretion whereas 5 microgram T3 q4h administered during the first 6 days of fasting did not increase 3-mehis excretion. Reverse T3 administration (80 microgram q6h) during fasting was associated with a mean 3-methylhistidine of 130 +/- 13 mumoles/day, a value no higher than in patients fasted alone. These observations suggest that: (1) skeletal muscle catabolism decreases during fasting: and (2) pathophysiologic doses of T3 (60 microgram/day or more), but not reverse T3, enhance muscle catabolism during fasting.
K D Burman, and
L Wartofsky, and
R E Dinterman, and
P Kesler, and
R W Wannemacher
August 1977,
The American journal of clinical nutrition,
K D Burman, and
L Wartofsky, and
R E Dinterman, and
P Kesler, and
R W Wannemacher
May 1977,
Clinical science and molecular medicine,
K D Burman, and
L Wartofsky, and
R E Dinterman, and
P Kesler, and
R W Wannemacher
November 1989,
Journal of the neurological sciences,
K D Burman, and
L Wartofsky, and
R E Dinterman, and
P Kesler, and
R W Wannemacher
October 1977,
Journal of neurology, neurosurgery, and psychiatry,
K D Burman, and
L Wartofsky, and
R E Dinterman, and
P Kesler, and
R W Wannemacher
June 1984,
Muscle & nerve,
K D Burman, and
L Wartofsky, and
R E Dinterman, and
P Kesler, and
R W Wannemacher
June 1980,
Revista espanola de fisiologia,
K D Burman, and
L Wartofsky, and
R E Dinterman, and
P Kesler, and
R W Wannemacher
November 1973,
Metabolism: clinical and experimental,
K D Burman, and
L Wartofsky, and
R E Dinterman, and
P Kesler, and
R W Wannemacher
December 1980,
Metabolism: clinical and experimental,
K D Burman, and
L Wartofsky, and
R E Dinterman, and
P Kesler, and
R W Wannemacher
December 1980,
Metabolism: clinical and experimental,
K D Burman, and
L Wartofsky, and
R E Dinterman, and
P Kesler, and
R W Wannemacher
January 1979,
The Biochemical journal,
