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By use of the galactose/NaB3H4 surface labeling technique followed by polyacrylamide slab gel electrophoresis, it is shown that the major labeled surface glycoprotein (GP130) of normal human blood granulocytes is markedly reduced in granulocytes from three patients with a chromosomal abnormality in all or most bone marrow mitoses. The abnormality consisted of monosomy-7 in two and deletion of the distal half of the long arm of chromosome-7 in the third. The granulocytes from these patients showed reduced chemotaxis. These results suggest that the expression of GP130, as well as the chemotactic ability of the cells, are at least in part controlled by one or several genes on chromosome-7. The GP130 protein may be involved in normal granulocyte chemotaxis.
C G Gahmberg, and
L C Andersson, and
P Ruutu, and
T T Timonen, and
A Hänninen, and
P Vuopio, and
A de la Chapelle
January 1977,
Nature,
C G Gahmberg, and
L C Andersson, and
P Ruutu, and
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A Hänninen, and
P Vuopio, and
A de la Chapelle
January 1982,
Haematologica,
C G Gahmberg, and
L C Andersson, and
P Ruutu, and
T T Timonen, and
A Hänninen, and
P Vuopio, and
A de la Chapelle
September 1978,
Biochimica et biophysica acta,
C G Gahmberg, and
L C Andersson, and
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A Hänninen, and
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A de la Chapelle
October 1981,
Blood,
C G Gahmberg, and
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A de la Chapelle
March 1977,
Experientia,
C G Gahmberg, and
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A de la Chapelle
February 1987,
The New England journal of medicine,
C G Gahmberg, and
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A de la Chapelle
March 1995,
Cancer genetics and cytogenetics,
C G Gahmberg, and
L C Andersson, and
P Ruutu, and
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A Hänninen, and
P Vuopio, and
A de la Chapelle
October 1974,
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C G Gahmberg, and
L C Andersson, and
P Ruutu, and
T T Timonen, and
A Hänninen, and
P Vuopio, and
A de la Chapelle
June 1982,
Cellular immunology,
C G Gahmberg, and
L C Andersson, and
P Ruutu, and
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A Hänninen, and
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A de la Chapelle
October 1990,
Cancer research,
