BIOMAT Database Logo BIOMAT Database Logo

HbF and HbA production in erythroid cultures from human fetuses and neonates. 1979

G Stamatoyannopoulos, and B B Rosenblum, and T Papayannopoulou, and M Brice, and B Nakamoto, and T H Shepard

UI MeSH Term Description Entries
D007231 Infant, Newborn An infant during the first 28 days after birth. Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D002478 Cells, Cultured Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others. Cultured Cells,Cell, Cultured,Cultured Cell
D005319 Fetal Hemoglobin The major component of hemoglobin in the fetus. This HEMOGLOBIN has two alpha and two gamma polypeptide subunits in comparison to normal adult hemoglobin, which has two alpha and two beta polypeptide subunits. Fetal hemoglobin concentrations can be elevated (usually above 0.5%) in children and adults affected by LEUKEMIA and several types of ANEMIA. Hemoglobin F,Hemoglobin, Fetal
D005333 Fetus The unborn young of a viviparous mammal, in the postembryonic period, after the major structures have been outlined. In humans, the unborn young from the end of the eighth week after CONCEPTION until BIRTH, as distinguished from the earlier EMBRYO, MAMMALIAN. Fetal Structures,Fetal Tissue,Fetuses,Mummified Fetus,Retained Fetus,Fetal Structure,Fetal Tissues,Fetus, Mummified,Fetus, Retained,Structure, Fetal,Structures, Fetal,Tissue, Fetal,Tissues, Fetal
D005865 Gestational Age The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated from the onset of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization. It is also estimated to begin from fertilization, estrus, coitus, or artificial insemination. Embryologic Age,Fetal Maturity, Chronologic,Chronologic Fetal Maturity,Fetal Age,Maturity, Chronologic Fetal,Age, Embryologic,Age, Fetal,Age, Gestational,Ages, Embryologic,Ages, Fetal,Ages, Gestational,Embryologic Ages,Fetal Ages,Gestational Ages
D005914 Globins A superfamily of proteins containing the globin fold which is composed of 6-8 alpha helices arranged in a characterstic HEME enclosing structure. Globin
D006412 Hematopoietic Stem Cells Progenitor cells from which all blood cells derived. They are found primarily in the bone marrow and also in small numbers in the peripheral blood. Colony-Forming Units, Hematopoietic,Progenitor Cells, Hematopoietic,Stem Cells, Hematopoietic,Hematopoietic Progenitor Cells,Cell, Hematopoietic Progenitor,Cell, Hematopoietic Stem,Cells, Hematopoietic Progenitor,Cells, Hematopoietic Stem,Colony Forming Units, Hematopoietic,Colony-Forming Unit, Hematopoietic,Hematopoietic Colony-Forming Unit,Hematopoietic Colony-Forming Units,Hematopoietic Progenitor Cell,Hematopoietic Stem Cell,Progenitor Cell, Hematopoietic,Stem Cell, Hematopoietic,Unit, Hematopoietic Colony-Forming,Units, Hematopoietic Colony-Forming
D006441 Hemoglobin A Normal adult human hemoglobin. The globin moiety consists of two alpha and two beta chains.
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

G Stamatoyannopoulos, and B B Rosenblum, and T Papayannopoulou, and M Brice, and B Nakamoto, and T H Shepard
Synthesis of HbA and HbF in erythroid colonies cultured from human fetal liver and umbilical cord blood.
November 1979, Blood,
G Stamatoyannopoulos, and B B Rosenblum, and T Papayannopoulou, and M Brice, and B Nakamoto, and T H Shepard
Fetal to adult hemoglobin switch in cultures of early erythroid precursors from human fetuses and neonates.
January 1979, American journal of hematology,
G Stamatoyannopoulos, and B B Rosenblum, and T Papayannopoulou, and M Brice, and B Nakamoto, and T H Shepard
Combined approaches for increasing fetal hemoglobin (HbF) and de novo production of adult hemoglobin (HbA) in erythroid cells from β-thalassemia patients: treatment with HbF inducers and CRISPR-Cas9 based genome editing.
January 2023, Frontiers in genome editing,
G Stamatoyannopoulos, and B B Rosenblum, and T Papayannopoulou, and M Brice, and B Nakamoto, and T H Shepard
Asynchronous synthesis of HbF and HbA during erythroblast maturation. II. Studies of G gamma, A gamma, and beta chain synthesis in individual erythroid clones from neonatal and adult BFU-E cultures.
March 1981, Blood,
G Stamatoyannopoulos, and B B Rosenblum, and T Papayannopoulou, and M Brice, and B Nakamoto, and T H Shepard
Cellular regulation of fetal hemoglobin synthesis in man. Investigation of gamma and beta mRNA accumulation in clonal erythroid cultures initiated from erythroid progenitors derived from fetuses, neonates, and adult individuals.
November 1980, Developmental biology,
G Stamatoyannopoulos, and B B Rosenblum, and T Papayannopoulou, and M Brice, and B Nakamoto, and T H Shepard
Membrane interactions of hemoglobin variants, HbA, HbE, HbF and globin subunits of HbA: effects of aminophospholipids and cholesterol.
January 2008, Biochimica et biophysica acta,
G Stamatoyannopoulos, and B B Rosenblum, and T Papayannopoulou, and M Brice, and B Nakamoto, and T H Shepard
Quantitative PCR analysis of HbF inducers in primary human adult erythroid cells.
February 2000, Blood,
G Stamatoyannopoulos, and B B Rosenblum, and T Papayannopoulou, and M Brice, and B Nakamoto, and T H Shepard
miR-326 regulates HbF synthesis by targeting EKLF in human erythroid cells.
July 2018, Experimental hematology,
G Stamatoyannopoulos, and B B Rosenblum, and T Papayannopoulou, and M Brice, and B Nakamoto, and T H Shepard
Techniques for studying stimulation of fetal hemoglobin production in human erythroid cultures.
January 1998, Hemoglobin,
G Stamatoyannopoulos, and B B Rosenblum, and T Papayannopoulou, and M Brice, and B Nakamoto, and T H Shepard
Regulation of the human HBA genes by KLF4 in erythroid cell lines.
June 2010, British journal of haematology,
Copied contents to your clipboard!