Phase II study of cis-dischlorodiammineplatinum(II) in stage IVB Hodgkin's disease. 1979

M P Corder, and T E Elliott, and L C Maguire, and J T Leimert, and S K Panther, and P A Lachenbruch

A broad phase II study of cis-dichlorodiammineplatinum(II) was conducted. Eight patients with stage IVB Hodgkin's disease were studied. Four of these patients attained an objective partial remission of 7--19+ weeks' duration. The usual time to the occurrence of a greater than 25% response was 1 week. This drug is active in far-advanced Hodgkin's disease with a projected lower limit of response rate from 19% to 21%.

UI MeSH Term Description Entries
D002945 Cisplatin An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle. Platinum Diamminodichloride,cis-Diamminedichloroplatinum(II),cis-Dichlorodiammineplatinum(II),Biocisplatinum,Dichlorodiammineplatinum,NSC-119875,Platidiam,Platino,Platinol,cis-Diamminedichloroplatinum,cis-Platinum,Diamminodichloride, Platinum,cis Diamminedichloroplatinum,cis Platinum
D004334 Drug Administration Schedule Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience. Administration Schedule, Drug,Administration Schedules, Drug,Drug Administration Schedules,Schedule, Drug Administration,Schedules, Drug Administration
D006689 Hodgkin Disease A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen. Granuloma, Hodgkin,Granuloma, Malignant,Hodgkin Lymphoma,Lymphogranuloma, Malignant,Granuloma, Hodgkin's,Granuloma, Hodgkins,Hodgkin Lymphoma, Adult,Hodgkin's Disease,Hodgkin's Lymphoma,Hodgkins Disease,Lymphocyte Depletion Hodgkin's Lymphoma,Lymphocyte-Rich Classical Hodgkin's Lymphoma,Mixed Cellularity Hodgkin's Lymphoma,Nodular Lymphocyte-Predominant Hodgkin's Lymphoma,Nodular Sclerosing Hodgkin's Lymphoma,Adult Hodgkin Lymphoma,Disease, Hodgkin,Disease, Hodgkin's,Disease, Hodgkins,Hodgkin Granuloma,Hodgkin's Granuloma,Hodgkins Granuloma,Hodgkins Lymphoma,Lymphocyte Rich Classical Hodgkin's Lymphoma,Lymphogranulomas, Malignant,Lymphoma, Hodgkin,Lymphoma, Hodgkin's,Malignant Granuloma,Malignant Granulomas,Malignant Lymphogranuloma,Malignant Lymphogranulomas,Nodular Lymphocyte Predominant Hodgkin's Lymphoma
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

M P Corder, and T E Elliott, and L C Maguire, and J T Leimert, and S K Panther, and P A Lachenbruch
April 1984, Gan to kagaku ryoho. Cancer & chemotherapy,
M P Corder, and T E Elliott, and L C Maguire, and J T Leimert, and S K Panther, and P A Lachenbruch
April 1977, Medizinische Klinik,
M P Corder, and T E Elliott, and L C Maguire, and J T Leimert, and S K Panther, and P A Lachenbruch
July 1981, Klinische Wochenschrift,
M P Corder, and T E Elliott, and L C Maguire, and J T Leimert, and S K Panther, and P A Lachenbruch
November 1984, Cancer,
M P Corder, and T E Elliott, and L C Maguire, and J T Leimert, and S K Panther, and P A Lachenbruch
October 1991, Cancer,
M P Corder, and T E Elliott, and L C Maguire, and J T Leimert, and S K Panther, and P A Lachenbruch
August 1986, Cancer treatment reports,
M P Corder, and T E Elliott, and L C Maguire, and J T Leimert, and S K Panther, and P A Lachenbruch
June 2004, Revue des maladies respiratoires,
M P Corder, and T E Elliott, and L C Maguire, and J T Leimert, and S K Panther, and P A Lachenbruch
April 1982, Gan to kagaku ryoho. Cancer & chemotherapy,
M P Corder, and T E Elliott, and L C Maguire, and J T Leimert, and S K Panther, and P A Lachenbruch
March 1982, Gan to kagaku ryoho. Cancer & chemotherapy,
M P Corder, and T E Elliott, and L C Maguire, and J T Leimert, and S K Panther, and P A Lachenbruch
January 1975, The American journal of roentgenology, radium therapy, and nuclear medicine,
Copied contents to your clipboard!