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In order to determine whether inhibition of the endometrial estradiol-17 beta-dehydrogenase activity by Cu++ could be one of the factors accounting for the enhanced contraceptive efficacy of copper intrauterine devices (Cu-IUD), the activity of the enzyme was measured in endometrial biopsies from women wearing this device. The levels of enzymatic activity found in these specimens were within the range of controls (women without IUD), e.g. 0.1--0.8 and 7--27 nmol E1 formed/mg protein/h in the follicular and luteal phases of the menstrual cycle, respectively. It is concluded that Cu-IUD does not modify significantly either the activity of endometrial-17 beta-dehydrogenase, an enzyme known to regulate the tissular concentration of estradiol, or its response to the inductive effect of progesterone.
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V Dramusic, and
E Gurpide
March 1980,
Biology of reproduction,
L Tseng, and
V Dramusic, and
E Gurpide
November 1991,
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L Tseng, and
V Dramusic, and
E Gurpide
February 1981,
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L Tseng, and
V Dramusic, and
E Gurpide
September 1982,
The Journal of clinical endocrinology and metabolism,
L Tseng, and
V Dramusic, and
E Gurpide
August 1969,
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L Tseng, and
V Dramusic, and
E Gurpide
June 1982,
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L Tseng, and
V Dramusic, and
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Orvosi hetilap,
L Tseng, and
V Dramusic, and
E Gurpide
February 1981,
The Journal of biological chemistry,
L Tseng, and
V Dramusic, and
E Gurpide
April 1970,
The Journal of biological chemistry,
L Tseng, and
V Dramusic, and
E Gurpide
January 1991,
Biochimica et biophysica acta,
