Using S. pyogenes as a tracer organism, an examination of the importance of air-borne infection of clean wounds in the modern, plenum-ventilated operating room has been made. It appears that, for most surgical procedures, additional ultra-clean air installations are not necessary. It has been shown that even if the air is sterile, the skin remains a possible source of infection. This is especially so as far as the patient's skin is concerned. It will remain so, since the skin cannot be sterilized. Indeed, until the ecology of the skin is better understood, rigorous efforts directed toward its disinfection may compromise its inherent defense mechanisms and its protective bacterial flora. It will be argued by some that operating rooms with ultraclean air should be afforded for certain specialized procedures in sugery; for example, those in which prosthetic materials are being implanted or in which the patient's immune mechanisms are depressed. Although not disagreeing with this, I wish to note that the only controlled trial on this aspect of surgery that exists to date shows no advantage for patients randomly apportioned to have hip arthroplasty, either in an isolator or in the same modern operating room but without the isolator. From this experience, I believe that any further trial of this nature, if it is to be controlled to a similar high level, will require very large numbers of patients to show even a marginal advantage for ultraclean air or isolator installations over the modern, plenum-ventilated and meticulously managed operating suite. The verdict on the need to install ultraclean air plant for operating rooms must, therefore, be couched in the third alternative that exists under Scots Law-- "not proved." I suggest the money could be better spent on devising methods to keep skin pathogens out of surgical wounds. Perhaps more urgently, there is a need to discover how to increase the defense mechanisms of the wound milieu to implanted harmful bacteria. There is also a pressing need to improve the ward environment with the aim of diminishing secondary infections of surgical wounds.