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Induction of sister chromatid exchanges (SCE's) was examined in bone marrow cells of young and old C57BL/6J mice exposed to three different DNA-damaging agents (cyclophosphamide, mitomycin C, and doxorubicin). At low concentrations of all three mutagens, the levels of induced SCE's were similar in young and old cell populations. However, at higher mutagen concentrations, SCE induction was significantly reduced in old cell populations. Studies of mice aged 5 to 32 months revealed that induced SCE frequencies remain stable during early adulthood (5 to 12 months) and then begin to decline as a function of age. These results indicate that with aging there exists a gradual alteration of cellular response to DNA damage.
Y Nakanishi, and
D Kram, and
E L Schneider
January 1980,
Cytogenetics and cell genetics,
Y Nakanishi, and
D Kram, and
E L Schneider
July 1978,
Experimental cell research,
Y Nakanishi, and
D Kram, and
E L Schneider
January 1979,
Human genetics,
Y Nakanishi, and
D Kram, and
E L Schneider
January 1984,
Environmental mutagenesis,
Y Nakanishi, and
D Kram, and
E L Schneider
April 1989,
Radiation research,
Y Nakanishi, and
D Kram, and
E L Schneider
August 1980,
Indian journal of experimental biology,
Y Nakanishi, and
D Kram, and
E L Schneider
June 2002,
Toxicology letters,
Y Nakanishi, and
D Kram, and
E L Schneider
February 1988,
Mutation research,
Y Nakanishi, and
D Kram, and
E L Schneider
February 1980,
Mutation research,
Y Nakanishi, and
D Kram, and
E L Schneider
August 1989,
Mutation research,
