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Basal and food-stimulated gastrin were measured in 16 patients with duodenal ulcer before and during long-term maintenance therapy with 400 mg cimetidine twice daily. Basal gastrin (mean +/- SE) rose significantly from 27.5 +/- 3.1 pmol/liter precimetidine to 32.8 +/- 2.1, 37.2 +/- 2.6, and 38.5 +/- 3.3 pmol/liter at 1, 3, and 6 months, respectively. The total integrated gastrin response to a protein meal was 1.67 +/- 0.18 nmol/liter/120 min pre-, and 2.54 +/- 0.35, 3.29 +/- 0.3, and 4.36 +/- 0.4 nmol/liter/120 min at 1, 3, and 6 months, respectively. These increases were significantly higher at each time period. This study has thus demonstrated a progressive increase in both basal and food-stimulated gastrin during cimetidine therapy, and this increase could theoretically lead to an increase in gastric acid secretion following cessation of cimetidine.
J Hansky, and
A I Stern, and
M G Korman, and
J Waugh
June 1979,
Digestive diseases and sciences,
J Hansky, and
A I Stern, and
M G Korman, and
J Waugh
October 1978,
Acta hepato-gastroenterologica,
J Hansky, and
A I Stern, and
M G Korman, and
J Waugh
January 1983,
Vutreshni bolesti,
J Hansky, and
A I Stern, and
M G Korman, and
J Waugh
July 1977,
Gastroenterology,
J Hansky, and
A I Stern, and
M G Korman, and
J Waugh
November 1978,
Zeitschrift fur Gastroenterologie,
J Hansky, and
A I Stern, and
M G Korman, and
J Waugh
February 1978,
Gastroenterology,
J Hansky, and
A I Stern, and
M G Korman, and
J Waugh
January 1976,
Arzneimittel-Forschung,
J Hansky, and
A I Stern, and
M G Korman, and
J Waugh
June 1979,
Gut,
J Hansky, and
A I Stern, and
M G Korman, and
J Waugh
January 1979,
Revista do Hospital das Clinicas,
J Hansky, and
A I Stern, and
M G Korman, and
J Waugh
January 1977,
Digestion,
