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The role of cord factor in BCG-induced pulmonary granulomas and local pulmonary delayed hypersensitivity (DH) was evaluated. Cord factor did not induce pulmonary granulomas comparable to those induced by killed BCG. The compound did not induce pulmonary DH that could be elicited by itself, purified protein derivative, or BCG. Cord factor-injected animals did not develop an accelerated pulmonary granulomatous response after challenge with killed BCG. Finally, cord factor did not elicit local pulmonary DH in BCG-sensitized animals. These results are discussed in relation to cord factor's role in antimicrobial immunity, granuloma formation, and antitumor immunity.
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