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The sites of labelling of DNA with [14C]methyl groups from methylbenzylnitrosamine and dimethylnitrosamine were studied in rat oesophageal epithelium and liver. All four combinations of tissue and carcinogen were studied. Tissues were labelled in vitro and the DNA contained therein purified and hydrolysed (pH 1, 37 degrees C) to free purines and apurinic acid. Quantitative analysis was performed with the aid of thin-layer chromatography. The apurinic acid and 7-methylguanine fractions were found to be extensively labelled. Smaller amounts of radioactivity were found in O6-methylguanine and some of the methylated adenines. The same carcinogen produced different patterns of labelling is oesophageal and liver DNA. The proportion of O6-methylguanine to 7-methylguanine was higher when the methylating agent was a carcinogen specific for the organ.
L Y Fong, and
H J Lin, and
C L Lee
November 1988,
Fundamental and applied toxicology : official journal of the Society of Toxicology,
L Y Fong, and
H J Lin, and
C L Lee
February 1977,
Chemico-biological interactions,
L Y Fong, and
H J Lin, and
C L Lee
February 1985,
Cancer letters,
L Y Fong, and
H J Lin, and
C L Lee
February 1973,
Chemico-biological interactions,
L Y Fong, and
H J Lin, and
C L Lee
March 1987,
Biochemical pharmacology,
L Y Fong, and
H J Lin, and
C L Lee
January 1981,
Carcinogenesis,
L Y Fong, and
H J Lin, and
C L Lee
January 1984,
IARC scientific publications,
L Y Fong, and
H J Lin, and
C L Lee
April 1991,
Carcinogenesis,
L Y Fong, and
H J Lin, and
C L Lee
January 1981,
Carcinogenesis,
L Y Fong, and
H J Lin, and
C L Lee
August 1976,
Biochemical pharmacology,
