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The systemic absorption of salicylic acid in humans following topical application in either hydrophilic ointment or polyethylene glycol 400 vehicle was studied. Drug absorption was minimal following application to intact skin; however, measurable levels (8 mg/dl) were attained when the stratum corneum was removed prior to application of the drug in hydrophilic ointment. A one-compartment open model with first order absorption and elimination processes was fitted to the plasma salicylate concentrations as a function of time. Computer simulations predict that plasma salicylate levels associated with toxicity in some patients may be present after repetitive application of the drug in hydrophilic ointment.
B K Birmingham, and
D S Greene, and
C T Rhodes
November 1983,
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B K Birmingham, and
D S Greene, and
C T Rhodes
January 2018,
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B K Birmingham, and
D S Greene, and
C T Rhodes
March 1885,
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B K Birmingham, and
D S Greene, and
C T Rhodes
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B K Birmingham, and
D S Greene, and
C T Rhodes
June 1975,
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B K Birmingham, and
D S Greene, and
C T Rhodes
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B K Birmingham, and
D S Greene, and
C T Rhodes
May 1978,
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B K Birmingham, and
D S Greene, and
C T Rhodes
February 1968,
Archives of ophthalmology (Chicago, Ill. : 1960),
B K Birmingham, and
D S Greene, and
C T Rhodes
August 1976,
The Journal of dermatology,
