Biomaterial Database

Pulmonary arterial distension and activity in phrenic nerve of anesthetized dogs. 1979

W O Kan, and J R Ledsome, and C P Bolter

In chloralose-anesthetized dogs a constant-flow, right atrium-to-left pulmonary artery, right-heart bypass was created. The right lung root was completely occluded and an isolated pouch of the main pulmonary arteries was perfused with venous blood at controlled nonpulsatile pressures between 10 and 90 Torr. An increase in pulmonary arterial pouch pressure caused an increase in systemic arterial pressure and in respiratory drive. In animals with afferent nerves intact, the increase in respiratory drive was indicated by an increase in the amplitude of the integrated phrenic electroneurogram. In animals with the left vagus nerve cut immediately above the left lung root, the increase in respiratory drive was evident by a shortening of the time of expiration. All responses were abolished by bilateral section of the cervical vagosympathetic trunks. It is concluded that in the preparation described pulmonary arterial distension causes a reflex increase in systemic vascular resistance and in respiratory drive, the afferent path of the reflex being in the vagus nerves.

UI	MeSH Term	Description	Entries
D010791	Phrenic Nerve	The motor nerve of the diaphragm. The phrenic nerve fibers originate in the cervical spinal column (mostly C4) and travel through the cervical plexus to the diaphragm.	Nerve, Phrenic,Nerves, Phrenic,Phrenic Nerves
D011311	Pressoreceptors	Receptors in the vascular system, particularly the aorta and carotid sinus, which are sensitive to stretch of the vessel walls.	Baroreceptors,Receptors, Stretch, Arterial,Receptors, Stretch, Vascular,Stretch Receptors, Arterial,Stretch Receptors, Vascular,Arterial Stretch Receptor,Arterial Stretch Receptors,Baroreceptor,Pressoreceptor,Receptor, Arterial Stretch,Receptor, Vascular Stretch,Receptors, Arterial Stretch,Receptors, Vascular Stretch,Stretch Receptor, Arterial,Stretch Receptor, Vascular,Vascular Stretch Receptor,Vascular Stretch Receptors
D011651	Pulmonary Artery	The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.	Arteries, Pulmonary,Artery, Pulmonary,Pulmonary Arteries
D012018	Reflex	An involuntary movement or exercise of function in a part, excited in response to a stimulus applied to the periphery and transmitted to the brain or spinal cord.
D012119	Respiration	The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (	Breathing
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D000200	Action Potentials	Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.	Spike Potentials,Nerve Impulses,Action Potential,Impulse, Nerve,Impulses, Nerve,Nerve Impulse,Potential, Action,Potential, Spike,Potentials, Action,Potentials, Spike,Spike Potential
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001166	Arteriovenous Shunt, Surgical	Surgical shunt allowing direct passage of blood from an artery to a vein. (From Dorland, 28th ed)	Shunt, Surgical Arteriovenous,Surgical Arteriovenous Shunt,Arteriovenous Shunts, Surgical,Shunts, Surgical Arteriovenous,Surgical Arteriovenous Shunts