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A standard intravenous 100 mug luteinizing hormone/follicle stimulating hormone-releasing hormone (LH/FSH-RH) test was used to assess the pituitary gonadotrophin responses in 155 patients with a variety of diseases of the hypothalamic-pituitary-gonadal axis. In all but nine patients there was an increase in circulating levels of either LH or FSH in response to the releasing hormone though 137 (88%) were clinically hypogonadal. It was not possible with this test to distinguish between hypothalamic and pituitary causes of hypogonadotrophic hypogonadism, since a variety of LH and FSH responses emerged within the disease groups. However, primary gonadal failure characteristically resulted in exaggerated gonadotrophin response. The potential therapeutic use of the gonadotrophin releasing decapeptide is suggested in certain patients with hypogonadotrophic hypogonadism.
C H Mortimer, and
G M Besser, and
A S McNeilly, and
J C Marshall, and
P Harsoulis, and
W M Tunbridge, and
A Gomez-Pan, and
R Hall
May 1988,
The Journal of urology,
C H Mortimer, and
G M Besser, and
A S McNeilly, and
J C Marshall, and
P Harsoulis, and
W M Tunbridge, and
A Gomez-Pan, and
R Hall
September 1973,
Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association,
C H Mortimer, and
G M Besser, and
A S McNeilly, and
J C Marshall, and
P Harsoulis, and
W M Tunbridge, and
A Gomez-Pan, and
R Hall
June 1974,
Endocrinologia japonica,
C H Mortimer, and
G M Besser, and
A S McNeilly, and
J C Marshall, and
P Harsoulis, and
W M Tunbridge, and
A Gomez-Pan, and
R Hall
August 1974,
American journal of obstetrics and gynecology,
C H Mortimer, and
G M Besser, and
A S McNeilly, and
J C Marshall, and
P Harsoulis, and
W M Tunbridge, and
A Gomez-Pan, and
R Hall
October 1975,
Obstetrics and gynecology,
C H Mortimer, and
G M Besser, and
A S McNeilly, and
J C Marshall, and
P Harsoulis, and
W M Tunbridge, and
A Gomez-Pan, and
R Hall
June 1967,
Endocrinologia japonica,
C H Mortimer, and
G M Besser, and
A S McNeilly, and
J C Marshall, and
P Harsoulis, and
W M Tunbridge, and
A Gomez-Pan, and
R Hall
March 1964,
Endocrinology,
C H Mortimer, and
G M Besser, and
A S McNeilly, and
J C Marshall, and
P Harsoulis, and
W M Tunbridge, and
A Gomez-Pan, and
R Hall
August 1974,
Experientia,
C H Mortimer, and
G M Besser, and
A S McNeilly, and
J C Marshall, and
P Harsoulis, and
W M Tunbridge, and
A Gomez-Pan, and
R Hall
June 1973,
Life sciences,
C H Mortimer, and
G M Besser, and
A S McNeilly, and
J C Marshall, and
P Harsoulis, and
W M Tunbridge, and
A Gomez-Pan, and
R Hall
April 1969,
The Journal of endocrinology,
