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Alterations in secretory patterns following vagotomy in rats with Pavlov or Heidenhain pouches. 1973

L Lundell, and S E Svensson

1. In conscious rats provided with Pavlov or Heidenhain pouches, the acid and pepsin secretion in response to feeding and infusion of gastrin was established before and after truncal vagotomy. In Pavlov pouches the responses to 2-deoxy-D-glucose, methacholine and the combination of gastrin and methacholine were also studied.2. Interdigestive secretion of acid and pepsin after vagotomy was decreased in the Pavlov pouch and increased in the Heidenhain pouch.3. The acid response to feeding in the Pavlov pouch was substantially reduced after vagotomy, whereas the secretion of pepsin was only slightly diminished.4. In the Heidenhain pouch after vagotomy, feeding augmented the high interdigestive secretion.5. After vagotomy, the acid dose-response curve to gastrin was shifted to the right in the Pavlov pouch and to the left in the Heidenhain pouch.6. In the Pavlov pouch after vagotomy, the acid response to the highest dose of methacholine employed was significantly enhanced.7. A background infusion of methacholine reestablished in the Pavlov pouch the reduced responsiveness to gastrin following vagotomy.8. Pepsin secretion was stimulated by gastrin in the Heidenhain pouch and after vagotomy in the Pavlov pouch. The stimulatory effect of methacholine on pepsin secretion in the Pavlov pouch was increased after vagotomy.

UI MeSH Term Description Entries
D008688 Methacholine Compounds A group of compounds that are derivatives of beta-methylacetylcholine (methacholine). Compounds, Methacholine
D010434 Pepsin A Formed from pig pepsinogen by cleavage of one peptide bond. The enzyme is a single polypeptide chain and is inhibited by methyl 2-diaazoacetamidohexanoate. It cleaves peptides preferentially at the carbonyl linkages of phenylalanine or leucine and acts as the principal digestive enzyme of gastric juice. Pepsin,Pepsin 1,Pepsin 3
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004435 Eating The consumption of edible substances. Dietary Intake,Feed Intake,Food Intake,Macronutrient Intake,Micronutrient Intake,Nutrient Intake,Nutritional Intake,Ingestion,Dietary Intakes,Feed Intakes,Intake, Dietary,Intake, Feed,Intake, Food,Intake, Macronutrient,Intake, Micronutrient,Intake, Nutrient,Intake, Nutritional,Macronutrient Intakes,Micronutrient Intakes,Nutrient Intakes,Nutritional Intakes
D005260 Female Females
D005502 Food Substances taken in by the body to provide nourishment. Foods
D005750 Gastric Juice The liquid secretion of the stomach mucosa consisting of hydrochloric acid (GASTRIC ACID); PEPSINOGENS; INTRINSIC FACTOR; GASTRIN; MUCUS; and the bicarbonate ion (BICARBONATES). (From Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p651) Gastric Juices,Juice, Gastric,Juices, Gastric
D005755 Gastrins A family of gastrointestinal peptide hormones that excite the secretion of GASTRIC JUICE. They may also occur in the central nervous system where they are presumed to be neurotransmitters. Gastrin
D005947 Glucose A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement. Dextrose,Anhydrous Dextrose,D-Glucose,Glucose Monohydrate,Glucose, (DL)-Isomer,Glucose, (alpha-D)-Isomer,Glucose, (beta-D)-Isomer,D Glucose,Dextrose, Anhydrous,Monohydrate, Glucose
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

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