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Fenoprofen, a compound with analgesic, anti-inflammatory, and antipyretic properties in animals, has been compared with placebo in a double-blind cross-over trial in 60 patients with rheumatoid arthritis. There was a statistically highly significant reduction in pain, duration of morning stiffness, analgesic requirements, and articular index, with increase in grip strength. There was no significant reduction in joint size or temperature. In a subsequent double-blind group-comparative study fenoprofen proved to be as effective as aspirin in relieving the symptoms of rheumatoid arthritis, with strikingly fewer side effects. Almost half of the patients taking aspirin were unable to tolerate the drug in adequate dosage for six months. The remainder were able to take on average only 4 g daily, and at this dose almost half still complained of tinnitus and deafness.Fenoprofen is likely to be useful for patients who cannot tolerate aspirin and other more toxic anti-inflammatory drugs or whose disease is not of sufficient severity to justify their use.
E C Huskisson, and
J A Wojtulewski, and
H Berry, and
J Scott, and
F D Hart, and
H W Balme
January 1977,
Clinical pharmacology and therapeutics,
E C Huskisson, and
J A Wojtulewski, and
H Berry, and
J Scott, and
F D Hart, and
H W Balme
January 1975,
Journal belge de rhumatologie et de medecine physique = Belgisch tijdschrift voor reumatologie en fysische geneeskunde,
E C Huskisson, and
J A Wojtulewski, and
H Berry, and
J Scott, and
F D Hart, and
H W Balme
January 1977,
Current therapeutic research, clinical and experimental,
E C Huskisson, and
J A Wojtulewski, and
H Berry, and
J Scott, and
F D Hart, and
H W Balme
January 1976,
The Journal of rheumatology,
E C Huskisson, and
J A Wojtulewski, and
H Berry, and
J Scott, and
F D Hart, and
H W Balme
March 1986,
The American journal of medicine,
E C Huskisson, and
J A Wojtulewski, and
H Berry, and
J Scott, and
F D Hart, and
H W Balme
January 1981,
Current medical research and opinion,
E C Huskisson, and
J A Wojtulewski, and
H Berry, and
J Scott, and
F D Hart, and
H W Balme
January 1976,
The Journal of rheumatology,
E C Huskisson, and
J A Wojtulewski, and
H Berry, and
J Scott, and
F D Hart, and
H W Balme
January 1976,
The Journal of rheumatology,
E C Huskisson, and
J A Wojtulewski, and
H Berry, and
J Scott, and
F D Hart, and
H W Balme
October 1969,
The British journal of clinical practice,
E C Huskisson, and
J A Wojtulewski, and
H Berry, and
J Scott, and
F D Hart, and
H W Balme
May 1956,
British medical journal,
