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The clinical effects of PC-904, a new semisynthetic penicillin, were studied in patients with biliary tract diseases, and the results were as follows: 1) PC-904 showed an average peak serum level of 40.7 +/- 11.6 microgram/ml 2 hours after an intravenous drip infusion of 1 g of the agent. The biliary level showed a peak value of 126.5 +/- 85.4 microgram/ml 2 hours to 3 hours after the infusion. 2) Isolated organisms from bile before the treatment were E. coli, Klebsiella, Proteus, Pseudomonas, Enterococcus and Bacteroides. MIC of PC-904 on 18 strains of isolated organisms was almost 6.25 microgram/ml or less. All isolated organisms except one strain of Klebsiella oxytoca disappeared after the treatment. 3) Six patients with cholelithiasis were medicated with PC-904 to prevent post-operative infections. The clinical effects were good in 4, poor in 1 and unknown in 1 case. 4) As to side effects no adverse reactions and allergic reactions were noted. Also no significant abnormalities of laboratory findings were observed.
K Ohhara, and
H Kubota, and
H Hashiba, and
T Kohchi, and
T Urushibara, and
N Kikuchi, and
T Yotsumoto, and
K Itoh, and
K Ichimura, and
T Uchida, and
A Kobayashi, and
H Kanno, and
N Kikuchi
July 1978,
The Japanese journal of antibiotics,
K Ohhara, and
H Kubota, and
H Hashiba, and
T Kohchi, and
T Urushibara, and
N Kikuchi, and
T Yotsumoto, and
K Itoh, and
K Ichimura, and
T Uchida, and
A Kobayashi, and
H Kanno, and
N Kikuchi
July 1978,
The Japanese journal of antibiotics,
K Ohhara, and
H Kubota, and
H Hashiba, and
T Kohchi, and
T Urushibara, and
N Kikuchi, and
T Yotsumoto, and
K Itoh, and
K Ichimura, and
T Uchida, and
A Kobayashi, and
H Kanno, and
N Kikuchi
July 1978,
The Japanese journal of antibiotics,
K Ohhara, and
H Kubota, and
H Hashiba, and
T Kohchi, and
T Urushibara, and
N Kikuchi, and
T Yotsumoto, and
K Itoh, and
K Ichimura, and
T Uchida, and
A Kobayashi, and
H Kanno, and
N Kikuchi
July 1978,
The Japanese journal of antibiotics,
K Ohhara, and
H Kubota, and
H Hashiba, and
T Kohchi, and
T Urushibara, and
N Kikuchi, and
T Yotsumoto, and
K Itoh, and
K Ichimura, and
T Uchida, and
A Kobayashi, and
H Kanno, and
N Kikuchi
March 1979,
The Japanese journal of antibiotics,
K Ohhara, and
H Kubota, and
H Hashiba, and
T Kohchi, and
T Urushibara, and
N Kikuchi, and
T Yotsumoto, and
K Itoh, and
K Ichimura, and
T Uchida, and
A Kobayashi, and
H Kanno, and
N Kikuchi
July 1978,
The Japanese journal of antibiotics,
K Ohhara, and
H Kubota, and
H Hashiba, and
T Kohchi, and
T Urushibara, and
N Kikuchi, and
T Yotsumoto, and
K Itoh, and
K Ichimura, and
T Uchida, and
A Kobayashi, and
H Kanno, and
N Kikuchi
July 1978,
The Japanese journal of antibiotics,
K Ohhara, and
H Kubota, and
H Hashiba, and
T Kohchi, and
T Urushibara, and
N Kikuchi, and
T Yotsumoto, and
K Itoh, and
K Ichimura, and
T Uchida, and
A Kobayashi, and
H Kanno, and
N Kikuchi
July 1978,
The Japanese journal of antibiotics,
K Ohhara, and
H Kubota, and
H Hashiba, and
T Kohchi, and
T Urushibara, and
N Kikuchi, and
T Yotsumoto, and
K Itoh, and
K Ichimura, and
T Uchida, and
A Kobayashi, and
H Kanno, and
N Kikuchi
July 1978,
The Japanese journal of antibiotics,
K Ohhara, and
H Kubota, and
H Hashiba, and
T Kohchi, and
T Urushibara, and
N Kikuchi, and
T Yotsumoto, and
K Itoh, and
K Ichimura, and
T Uchida, and
A Kobayashi, and
H Kanno, and
N Kikuchi
July 1978,
The Japanese journal of antibiotics,
