Experiments were conducted on dogs under conditions of closed chest catheterization and autoperfusion of the coronary vessels to study the methods and manipulations providing reliable reproduction of previously planned direct restriction of coronary blood flow, strictly dosed in degree and duration, simulating coronary insufficiency of various severity. The use of this complex of methods and manipulations makes it possible to avoid the shortcomings and undesirable consequences of denervation of the coronary arteries and their extravascular mechanical compression and the need to open the chest. The simulated restriction of coronary blood flow is reversible owing to which it may be reproduce many time in one experiment.