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Rinderpest virus infection was shown to induce marked suppression of both humoral antibody response and cell-mediated immunity in rabbits. The virus exhibited a suppressive effect on primary antibody response as indicated by a decrease in numbers of plaque-forming cells (immunoglobulin [Ig]M) and hemagglutinating antibody titers of both IgM and IgG types to sheep red blood cells, whereas there was no detectable effect of the virus on the production of memory cells. Virus-induced suppression of cell-mediated immunity was demonstrated by a decreased rate of proliferative response of peripheral lymphocytes to phytohemagglutinin stimulus and by a depression of delayed-type skin reactions to purified protein derivative. Such suppressive effects were indicated to persist for 14 days or longer. Alteration in phagocytic activity of the reticuloendothelial system was not observed. The relevance of the virus-induced histological lesions in the lymphoid tissues to the virus-induced immunosuppression was discussed.
K Yamanouchi, and
A Fukuda, and
F Kobune, and
Y Yoshikawa, and
F Chino
April 1994,
Acta virologica,
K Yamanouchi, and
A Fukuda, and
F Kobune, and
Y Yoshikawa, and
F Chino
April 1998,
Comparative immunology, microbiology and infectious diseases,
K Yamanouchi, and
A Fukuda, and
F Kobune, and
Y Yoshikawa, and
F Chino
April 2002,
Veterinary research communications,
K Yamanouchi, and
A Fukuda, and
F Kobune, and
Y Yoshikawa, and
F Chino
October 1959,
Journal of comparative pathology,
K Yamanouchi, and
A Fukuda, and
F Kobune, and
Y Yoshikawa, and
F Chino
May 1987,
The Journal of infectious diseases,
K Yamanouchi, and
A Fukuda, and
F Kobune, and
Y Yoshikawa, and
F Chino
June 1964,
The Journal of hygiene,
K Yamanouchi, and
A Fukuda, and
F Kobune, and
Y Yoshikawa, and
F Chino
January 1988,
Archives of virology,
K Yamanouchi, and
A Fukuda, and
F Kobune, and
Y Yoshikawa, and
F Chino
October 1976,
Japanese journal of medical science & biology,
K Yamanouchi, and
A Fukuda, and
F Kobune, and
Y Yoshikawa, and
F Chino
December 1965,
The Journal of hygiene,
K Yamanouchi, and
A Fukuda, and
F Kobune, and
Y Yoshikawa, and
F Chino
August 1958,
Science (New York, N.Y.),
