Biomaterial Database

Transport of D-arabinose-5-phosphate and D-sedoheptulose-7-phosphate by the hexose phosphate transport system of Salmonella typhimurium. 1974

L Eidels, and P D Rick, and N P Stimler, and M J Osborn

d-Arabinose-5-phosphate and d-sedoheptulose-7-phosphate were found to be substrates, although not inducers, of the hexose phosphate transport system of Salmonella typhimurium. Transport of these two sugar phosphates by wild-type strains required preinduction of the hexose phosphate transport system. A mutant of S. typhimurium constitutive for this system also transported d-arabinose-5-phosphate and d-sedoheptulose-7-phosphate in a constitutive fashion. Glucose-6-phosphate was a potent competitor of the transport of both d-arabinose-5-phosphate and d-sedoheptulose-7-phosphate. The K(m) values for transport of d-glucose-6-phosphate, d-arabinose-5-phosphate, and d-sedoheptulose-7-phosphate were 0.13, 0.32 and 1.61 mM, respectively. The apparent V(max) values for transport of d-glucose-6-phosphate, d-arabinose-5-phosphate, and d-sedoheptulose-7-phosphate were 6.3, 13.2 and 3.0 nmol per min per 5 x 10(8) bacteria, respectively. d-Ribulose-5-phosphate and d-xylulose-5-phosphate did not inhibit transport of the above substrates, whereas d-ribose-5-phosphate was a weak inhibitor of d-sedoheptulose-7-phosphate transport.

UI	MeSH Term	Description	Entries
D009154	Mutation	Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.	Mutations
D010428	Pentosephosphates
D002250	Carbon Radioisotopes	Unstable isotopes of carbon that decay or disintegrate emitting radiation. C atoms with atomic weights 10, 11, and 14-16 are radioactive carbon isotopes.	Radioisotopes, Carbon
D002621	Chemistry	A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.
D004790	Enzyme Induction	An increase in the rate of synthesis of an enzyme due to the presence of an inducer which acts to derepress the gene responsible for enzyme synthesis.	Induction, Enzyme
D005947	Glucose	A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.	Dextrose,Anhydrous Dextrose,D-Glucose,Glucose Monohydrate,Glucose, (DL)-Isomer,Glucose, (alpha-D)-Isomer,Glucose, (beta-D)-Isomer,D Glucose,Dextrose, Anhydrous,Monohydrate, Glucose
D005958	Glucosephosphates
D006539	Heptoses
D001089	Arabinose		L-Arabinose,L Arabinose
D001693	Biological Transport, Active	The movement of materials across cell membranes and epithelial layers against an electrochemical gradient, requiring the expenditure of metabolic energy.	Active Transport,Uphill Transport,Active Biological Transport,Biologic Transport, Active,Transport, Active Biological,Active Biologic Transport,Transport, Active,Transport, Active Biologic,Transport, Uphill