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The 3-angstrom electron density map of crystalline yeast phenylalanine transfer RNA has provided us with a complete three-dimensional model which defines the positions of all of the nucleotide residues in the moleclule. The overall features of the molecule are virtually the same as those seen at a resolution of 4 angstroms except that many additional details of tertiary structure are now visualized. Ten types of hydrogen bonding are identified which define the specificity of tertiary interactions. The molecule is also stabilized by considerable stacking of the planar purines and pyrimidines. This tertiary structure explains, in a simple and direct fashion, chemical modification studies of transfer RNA. Since most of the tertiary interactions involve nucleotides which are common to all transfer RNA 's, it is likely that this three-dimensional structure provides a basic pattern of folding which may help to clarify the three-dimensional structure of all transfer RNA's.
S H Kim, and
F L Suddath, and
G J Quigley, and
A McPherson, and
J L Sussman, and
A H Wang, and
N C Seeman, and
A Rich
January 1976,
Progress in nucleic acid research and molecular biology,
S H Kim, and
F L Suddath, and
G J Quigley, and
A McPherson, and
J L Sussman, and
A H Wang, and
N C Seeman, and
A Rich
November 1975,
Proceedings of the National Academy of Sciences of the United States of America,
S H Kim, and
F L Suddath, and
G J Quigley, and
A McPherson, and
J L Sussman, and
A H Wang, and
N C Seeman, and
A Rich
August 1978,
Journal of molecular biology,
S H Kim, and
F L Suddath, and
G J Quigley, and
A McPherson, and
J L Sussman, and
A H Wang, and
N C Seeman, and
A Rich
April 1969,
Biochemical and biophysical research communications,
S H Kim, and
F L Suddath, and
G J Quigley, and
A McPherson, and
J L Sussman, and
A H Wang, and
N C Seeman, and
A Rich
January 1978,
Scientific American,
S H Kim, and
F L Suddath, and
G J Quigley, and
A McPherson, and
J L Sussman, and
A H Wang, and
N C Seeman, and
A Rich
January 1975,
Biochemical Society transactions,
S H Kim, and
F L Suddath, and
G J Quigley, and
A McPherson, and
J L Sussman, and
A H Wang, and
N C Seeman, and
A Rich
March 1967,
Proceedings of the National Academy of Sciences of the United States of America,
S H Kim, and
F L Suddath, and
G J Quigley, and
A McPherson, and
J L Sussman, and
A H Wang, and
N C Seeman, and
A Rich
January 1976,
Biochemical and biophysical research communications,
S H Kim, and
F L Suddath, and
G J Quigley, and
A McPherson, and
J L Sussman, and
A H Wang, and
N C Seeman, and
A Rich
August 1978,
Journal of molecular biology,
S H Kim, and
F L Suddath, and
G J Quigley, and
A McPherson, and
J L Sussman, and
A H Wang, and
N C Seeman, and
A Rich
November 1974,
Journal of molecular biology,
