BIOMAT Database Logo BIOMAT Database Logo

Relationships between the carcinogenic and mutagenic or DNA-modifying effects of nitrofuran derivatives, including 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide, a food additive. 1974

T Yahagi, and M Nagao, and K Hara, and T Matsushima, and T Sugimura, and G T Bryan

UI MeSH Term Description Entries
D009153 Mutagens Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes. Clastogen,Clastogens,Genotoxin,Genotoxins,Mutagen
D009581 Nitrofurans Compounds containing FURANS attached to a nitro group.
D009583 Nitrofurazone A topical anti-infective agent effective against gram-negative and gram-positive bacteria. It is used for superficial WOUNDS AND INJURIES and skin infections. Nitrofurazone has also been administered orally in the treatment of TRYPANOSOMIASIS. Nitrofural,Furacilin,Furacillin,Furacin,Nitrofurazone, Calcium (2:1) Salt
D002273 Carcinogens Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included. Carcinogen,Oncogen,Oncogens,Tumor Initiator,Tumor Initiators,Tumor Promoter,Tumor Promoters,Initiator, Tumor,Initiators, Tumor,Promoter, Tumor,Promoters, Tumor
D004260 DNA Repair The removal of DNA LESIONS and/or restoration of intact DNA strands without BASE PAIR MISMATCHES, intrastrand or interstrand crosslinks, or discontinuities in the DNA sugar-phosphate backbones. DNA Damage Response
D004269 DNA, Bacterial Deoxyribonucleic acid that makes up the genetic material of bacteria. Bacterial DNA
D004926 Escherichia coli A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc. Alkalescens-Dispar Group,Bacillus coli,Bacterium coli,Bacterium coli commune,Diffusely Adherent Escherichia coli,E coli,EAggEC,Enteroaggregative Escherichia coli,Enterococcus coli,Diffusely Adherent E. coli,Enteroaggregative E. coli,Enteroinvasive E. coli,Enteroinvasive Escherichia coli
D005503 Food Additives Substances used in the processing or storage of foods or animal feed including ANTIOXIDANTS; FOOD PRESERVATIVES; FOOD COLORING AGENTS; FLAVORING AGENTS; ANTI-INFECTIVE AGENTS; EXCIPIENTS and other similarly used substances. Many of the same substances are used as PHARMACEUTIC AIDS. Additive, Food,Additives, Food,Food Additive
D000178 Acrylamides Colorless, odorless crystals that are used extensively in research laboratories for the preparation of polyacrylamide gels for electrophoresis and in organic synthesis, and polymerization. Some of its polymers are used in sewage and wastewater treatment, permanent press fabrics, and as soil conditioning agents.
D012486 Salmonella typhimurium A serotype of Salmonella enterica that is a frequent agent of Salmonella gastroenteritis in humans. It also causes PARATYPHOID FEVER. Salmonella typhimurium LT2

Related Publications

T Yahagi, and M Nagao, and K Hara, and T Matsushima, and T Sugimura, and G T Bryan
Carcinogenic activity of 2-(2-furyl)-3-(5-nitro-2-furyl)-acrylamide, a food additive, in mice and rats.
September 1977, Cancer letters,
T Yahagi, and M Nagao, and K Hara, and T Matsushima, and T Sugimura, and G T Bryan
Statistical analysis on toxicity of a nitrofuran derivative, 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide.
February 1975, The Tohoku journal of experimental medicine,
T Yahagi, and M Nagao, and K Hara, and T Matsushima, and T Sugimura, and G T Bryan
AF-2 [2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide].
July 1983, IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans,
T Yahagi, and M Nagao, and K Hara, and T Matsushima, and T Sugimura, and G T Bryan
[Studies on nitrofuran derivatives. VI. Synthesis of 2-(5-nitro-2-furyl)vinylpyridinemethanol and 2-(5-nitro-2-furyl)vinylpyridinecarboxylic acid derivatives].
November 1966, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
T Yahagi, and M Nagao, and K Hara, and T Matsushima, and T Sugimura, and G T Bryan
Studies on nitrofuran derivatives. 8. Synthesis of 3-(5-nitro-2-furyl)isoxazoles.
November 1967, Chemical & pharmaceutical bulletin,
T Yahagi, and M Nagao, and K Hara, and T Matsushima, and T Sugimura, and G T Bryan
Studies on nitrofuran derivatives. IV. Synthesis of 2- or 4-[2-(5-nitro-2-furyl)vinyl]pyrimidine derivatives.
October 1965, Chemical & pharmaceutical bulletin,
T Yahagi, and M Nagao, and K Hara, and T Matsushima, and T Sugimura, and G T Bryan
[Synthesis of nitrofuran derivatives. 32. Preparation of cis- and trans-3-(5-nitro-2-furyl)acrylic acid and 2-alkyl-3-(5-nitro-2-furyl)acrylic acids by Perkin reaction].
March 1963, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
T Yahagi, and M Nagao, and K Hara, and T Matsushima, and T Sugimura, and G T Bryan
[Synthesis of nitrofuran derivatives. IX. Reactions of diethyl 3-(5-nitro-2-furyl)acryloylmalonate with amines].
December 1966, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
T Yahagi, and M Nagao, and K Hara, and T Matsushima, and T Sugimura, and G T Bryan
Structure and antischistosomal activity in the nitrofuran series. Requirement for a 5-nitro group in 3-(5-nitro-2-furyl)acrylic acid derivatives.
January 1973, Journal of medicinal chemistry,
T Yahagi, and M Nagao, and K Hara, and T Matsushima, and T Sugimura, and G T Bryan
[Synthesis of nitrofuran derivatives. VII. Synthesis of 2-[2-(5-nitro-2-furyl) vinyl]-2-imidazoline].
June 1966, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
Copied contents to your clipboard!